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Flashcards in Skin V Deck (46):
1

cat-scratch disease is caused by which organism?

cat-scratch disease is caused by B. henselae

2

in ____ patients, baciliary angiomatosis can occur 

in AIDS patients, baciliary angiomatosis can occur 

3

describe the clinical presentation of cat-scratch disease

  • self-limited regional lymphadenopathy
  • persistent infection of erythrocytes and endothelial cells
    • can trigger proliferation of endothelial cells (vascular tumor formation)

4

in cat-scratch disease, there is self-limited regional _____

in cat-scratch disease, there is self-limited regional lymphadenopathy

5

in cat scratch disease, there is persistent infection of ___ and ___ cells

in cat scratch disease, there is persistent infection of erythrocytes and endothelial cells

6

the persistent infection of ____ cells in cat scratch disease can lead to ____ formation

the persistent infection of endothelial cells in cat scratch disease can lead to vascular tumor formation

7

upon physical examination of a patient with cat scratch disease, there is an enlarged ____

upon physical examination of a patient with cat scratch disease, there is an enlarged spleen

8

_____ testing is confirmatory of cat scratch disease

serologic testing is confirmatory of cat scratch disease

9

describe the DNA virus classification tree

10

describe the RNA virus classification tree

11

list the 2 diseases that have a centripetal rash

rubella and measles

12

list the 2 diseases that have a centrifugal rash

(centrifugal = fugitive = going outwards)

roseola and chickenpox

13

describe the viral classification of Rubeola virus

large, enveloped, (-) ssRNA

14

Rubeloa virus is part of the ____ family

Rubeloa virus is part of the Paramyxoviridae family

15

list the important envelope proteins present on Rubeola virus

  • F (fusion) protein:
    • fusion to host cell membranes, viral penetration and hemolysis
  • H (hemagglutinin) protein:
    • adsorption of virus to cells (NO neuraminidase)

16

Rubeola does NOT contain ___ as an envelope protein

Rubeola does NOT contain neuraminidase as an envelope protein

17

list the 4 C's of measles 

  • cough
  • coryza
  • conjunctivitis (with photophobia)
  • Coplik spots (Koplik)

18

____ rash appears after Koplik's spots dissappear

maculopapular rash appears after Koplik's spots dissappear

19

in measles, the rash that forms is described as (centripetal or centrifugal?)

in measles, the rash that forms is described as centripetal

20

in measles, there is generalized ____ and a complication is lifelong ____

in measles, there is generalized lymphadenopathy and a complication is lifelong disabilities (brain damage, blindness, deafness)

21

the rash seen in measles is caused by ___ damage of ____ cells

the rash seen in measles is caused by cytotoxic T cell damage of infected endothelial cells

22

the measles virus binds to ___ of most cells

the measles virus binds to CD46 of most cells

23

the measles virus infects ____ lymphocytes and dendritic cells, followed by virus transmission to ____ expressing epithelial cells (skin)

the measles virus infects CD150 lymphocytes and dendritic cells, followed by virus transmission to nectin-4 expressing epithelial cells (skin)

24

measles causes immunosuppression during the infection, but after resolution, there is _____

measles causes immunosuppression during the infection, but after resolution, there is lifelong immunity

25

prevention of measles is via a ____

prevention of measles is via a live attenuated vaccine

26

describe the Sketchy in relation to measles

27

Rubella (German measles) is part of the ___ family of viruses

Rubella (German measles) is part of the togaviridae family of viruses

enveloped +ssRNA

28

describe the viral composition of Rubella virus

enveloped, (+)ssRNA

29

the clinical presentation of rubella is very ___, but has a characteristic _____ lymphadenopathy

the clinical presentation of rubella is very mild, but has a characteristic postauricular lymphadenopathy

30

the rash seen in rubella spreads in a (centripetal or centrifugal?) pattern

the rash seen in rubella spreads in a centripetal pattern

31

describe the birth defects that can occur from Rubella

growth retardation, cataracts, deafness, congenital heart defects

I (eye) ♥ Ruby Earrings 

32

rubella is transmitted via ____ 

rubella is transmitted via aerosol droplets

33

diagnosis of rubella is by seeing a 4x increase in ___ or ____

diagnosis of rubella is by seeing a 4x increase in IgG antibody or IgM (+)

34

in pregnant woman with history of contact with rubella, ___ can be recommended

it can reduce symptoms but DOES NOT eliminate the possibility of the baby developing congenital rubella syndrome

in pregnant woman with history of contact with rubella, hyperimmune globulin can be recommended

it can reduce symptoms but DOES NOT eliminate the possibility of the baby developing congenital rubella syndrome

35

36

roseola infantum virus is part of the ____ family of viruses

roseola infantum virus is part of the Herpesvirus family of viruses

enveloped dsDNA

37

the rash seen in roseola is described as (centripetal or centrifugal?)

the rash seen in roseola is described as centrifugal

38

roseola infantum can cause febrile ____

roseola infantum can cause febrile seizures

39

in roseola infantum, there are pink ___ and ____ surrounded by white ____

in roseola infantum, there are pink macules and papules surrounded by white halos

40

roseola infantum replicates in ___ and ___

 

roseola infantum replicates in leukocytes and salivary glands

41

roseola uses ___ to enter leukocytes

roseola uses CD46 protein to enter leukocytes

42

roseola uses ___ to enter leukocytes

roseola uses CD46 to enter leukocytes

43

Fifth disease is caused by ____

describe the viral composition

Fifth disease is caused by Parvovirus B19

non-enveloped, linear ssDNA icosahedral

44

erythema infectiosum causes a ____ appearance on the face of children

while 

adults might have ____ and swelling

erythema infectiosum causes a "slapped cheek" appearance on the face of children

while 

adults might have joint pain and swelling

45

the receptor for Fifth disease (erythema infectiosum) is the ___ located on the ____

the receptor for Fifth disease (erythema infectiosum ) is the P antigen located on the erythrocyte precursor

46

Fifth disease can be serious in pregnant women, where it can cause severe ___ in newborns or it can also cause ___

Fifth disease can be serious in pregnant women, where it can cause severe anemia in newborns or it can also cause miscarriage