Sarcoidosis Flashcards Preview

Respiratory Diseases > Sarcoidosis > Flashcards

Flashcards in Sarcoidosis Deck (9)
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1
Q

what is it

A

granulomatous disease of unknown cause

2
Q

what is a granuloma

A

mass or nodule composed of chronically inflamed tissue formed by response of mononuclear phagocyte system to insoluble or slowly soluble antigen

3
Q

what type of hypersensitivity

A

type 4

4
Q

what systems commonly involved

A

lungs, lymph nodes, joints, liver, skin, eyes

5
Q

what are symptoms of acute sarcoidosis

A
sweats 
erythema nodosum (skin lesion)
6
Q

what are symptoms of chronic sarcoidosis

A
lung infiltrates/alveolitis (scarring)
skin infiltrates 
peripheral lymphadenopathy
hypercalcaemia 
SOB 
persistent dry cough 
rashes on body
7
Q

how is it diagnosed

A

CXR - bilateral hilum lymphadenopathy
CT - check for peripheral nodular infiltrates
Bloods - raised calcium and inflammatory markers
Restrictive PFT

8
Q

what is treatment of acute sarcoidosis

A

usually do not need specific treatment
paracetamol
anti-inflammatory

9
Q

what is treatment of chronic sarcoidosis

A
oral steroid (prednisolone) 
immunosuppression (azathioprine, methotrexate)