Serum Sickness Flashcards
1
Q
What antibodies lead to activation of complement system and what pathway do they activate
A
IgM, IgG1, IgG2, IgG3
These all activate the classical pathway.
IgG4 activate the alternative pathway.
2
Q
What is the mechanism of action of these antibodies
A
They form immune complexes which bind to C1q
3
Q
What is a chimeric antibody
A
Mouse Fab region with a human Fc region
4
Q
Patients who are treated with rituximab how do we check their B cell numbers
A
Look for CD 19 since all the CD20 is bound with Rituximab
5
Q
How are immune complexes cleared?
A
They are removed by phagocytes
6
Q
Rheumatoid factor
A
We make IgM antibodies to our IgG antibodies
7
Q
Localized serum sickness is called?
A
Arthus reaction
