Serum Sickness Flashcards Preview

Inflammation and Immunity > Serum Sickness > Flashcards

Flashcards in Serum Sickness Deck (7):
1

What antibodies lead to activation of complement system and what pathway do they activate

IgM, IgG1, IgG2, IgG3

These all activate the classical pathway.
IgG4 activate the alternative pathway.

2

What is the mechanism of action of these antibodies

They form immune complexes which bind to C1q

3

What is a chimeric antibody

Mouse Fab region with a human Fc region

4

Patients who are treated with rituximab how do we check their B cell numbers

Look for CD 19 since all the CD20 is bound with Rituximab

5

How are immune complexes cleared?

They are removed by phagocytes

6

Rheumatoid factor

We make IgM antibodies to our IgG antibodies

7

Localized serum sickness is called?

Arthus reaction