eLearnings Flashcards Preview

Inflammation and Immunity > eLearnings > Flashcards

Flashcards in eLearnings Deck (13)
Loading flashcards...

Microcytic Anemia

Low MCV, iron deficiency


Macrocytic Anemia

High MCV, B12 deficiency


Increase Sed rate (ESR)

A measure for an ongoing inflammatory process


What is present in the blood that causes the ESR to become high

Acute phase proteins


What is another component of CBC that can be used as a measure of ongoing inflammation

C reactive proteins


Lowering of all blood cells count



What does epinephrine do to the neutrophil count in the blood

Increases it, increases the circulating neutrophils in the blood stream


Define electrophoresis

Method of separating molecules based on their charge and mass


Results of SPE (Serum Protein Electrophoresis)

We see a plot of relative densities (on y axis) against the type of proteins (on x axis). There are 5 peaks that are observed. The most dense protein is the albumin protein with the highest peak. Then the peaks are alpha (1,2), beta and gamma which are for globulins.


Explain the 4 peaks

Alpha 1 - Serum protease inhibitor, loss of it is associated with emphysema

Alpha 2 - protease inhibitor, increased conc. during acute phase reaction

Beta - Iron binding proteins and also IgA, IgM and some complement proteins. Know why IgA and IgM are in this

Gamma- IgG



Some proteins are small enough to pass in the urine such as light chain and so a Urine Protein Electrophoresis can be done to check for gammopathies


Explain spikes that may be observed in SPE

Spikes originating in the gamma globulin region indicates an increase in a certain type of monoclonal antibodies. This can be due to infection or lymphoma


Is SPE quantitative or qualitative

It is qualitative, quantitative testing is often required and done along with SPE