Flashcards in Sjogren Syndrome Deck (14):
What is Sjogren (Sjo) syndrome?
Chronic inflammatory disorder characterized by lymphatic infiltration of the exocrine glands
Which exocrine glands are primarily infiltrated?
Lacrimal and Salivary
Sjo characterized by what?
Dryness of eyes and mouth
How can Sjo present?
By itself or combined with SLE, RA
Unknown, thought to be genetic with viral initiator
What genetic bases are there for Sjo?
Increased HLA DR3
What viral titers have been associated with Sjo?
EBV, CMV, HHV6
What is commonly found in salivary glands of Sjo patients?
Coxsackie virus RNA
Which hepatitis can cause Sjo?
How do you diagnose ocular manifestations of Sjo?
Slitlamp: superficial erosions of corneal epithelium
Systemic manifestation of Sjo?
Trigeminal, autonomic neuropathy
Dementia, lesions that mimic multiple sclerosis
Lymphomas of which cell line are common?