Sjogren Syndrome Flashcards Preview

ICM Infectious Disease > Sjogren Syndrome > Flashcards

Flashcards in Sjogren Syndrome Deck (14):
1

What is Sjogren (Sjo) syndrome?

Chronic inflammatory disorder characterized by lymphatic infiltration of the exocrine glands

2

Which exocrine glands are primarily infiltrated?

Lacrimal and Salivary

3

Sjo characterized by what?

Dryness of eyes and mouth

4

How can Sjo present?

By itself or combined with SLE, RA

5

EtiologY?

Unknown, thought to be genetic with viral initiator

6

What genetic bases are there for Sjo?

Familial tendency
Increased HLA DR3

7

What viral titers have been associated with Sjo?

EBV, CMV, HHV6

8

What is commonly found in salivary glands of Sjo patients?

Retrovirus HTLV-1
Coxsackie virus RNA

9

Which hepatitis can cause Sjo?

C

10

How do you diagnose ocular manifestations of Sjo?

Slitlamp: superficial erosions of corneal epithelium
Schirmir test:

11

Systemic manifestation of Sjo?

Fatigue

12

Neurologic manifestation?

Trigeminal, autonomic neuropathy
Dementia, lesions that mimic multiple sclerosis

13

Lymphomas of which cell line are common?

B-cell line

14

GI manifestations?

Rare malabsorption
Esophageal dysmotility
Mild pancreatitis