Vasculitis Flashcards Preview

ICM Infectious Disease > Vasculitis > Flashcards

Flashcards in Vasculitis Deck (32):
1

Vasculitis can lead to what?

Necrosis of vessel wall with perforation and hemorrhage into adjacent tissues. Occlusion of vessel can lead to distal ischemia and infarction of tissue

2

What organisms can cause infectious vasculitis?

Rickettsia, Syphilis, Aspergillus

3

What can cause noninfectious vasculitis?

Autoimmune response to known pathogen such as Cryoglobulinemic vasculitis and Hep C infection

4

Types of large vessel vasculitis (2)?

Takayasu
Giant Cell Arteritis

5

Who does Takayasu present in?

Younger patients with clarification of extremities

6

Telltale sign of Takayasu?

BP diff between extremities, bruit over subclavian artery/aorta

7

Treatment of Takayasu?

High dose corticosteroids

8

Giant cell arteritis presents in who?

Older patients > 50 with headache, visual loss, jaw claudication

9

Major worry from Giant cell arteritis?

Blindness

10

Gold standard of diagnosis for GCA?

Temporal artery biopsy
Elevated ESR

11

Treatment for GCA?

High dose corticosteroid

12

GCA associated with what other disease?

Polymyalgia Rheumatica

13

What is Polymyalgia Rheumatica?

Sudden onset of pain and stiffness in shoulders and hips in people > 50 with high ESR

14

Types of Medium Vessel Vasculitis? 2

Polyarteritis Nodosum
Kawasaki Disease

15

Polyarteritis Nodosum (PAN) most commonly involved organ?

Kidney with Elevated BUN/Creatinine and Elevated BP

16

Treatment for PAN?

High dose corticosteroids, Cyclophophamide, plasmapheresis

17

Who does Kawasaki disease occur in?

Childhood disease, but can occur in adults

18

What can Kawasaski disease lead to?

Coronary artery aneurysms, depressed myocardial contractility, heart failure, myocardial infarction, arrhythmia, and peripheral arterial occlusion.

19

Treatment for Kawasaki?

IVIG within first 10 days
Aspirin

20

What Small vessel vasculitis are there? (3)

Microscopic polyangiitis
Granulomatosis with polyangitis
Eosinophillic granulomatosis with polyangitis

21

What does ANCA stand for?

Antibodies against Neutrophil Cytoplasmic Antigens

22

What does Microscopic polyangiitis affect?

Lungs and Kidneys

23

Lab work for Microscopic polyangiitis shows up as?

ANCA positive
Renal biopsy shows not granulomatous inflammation

24

In Granulomatosis with polyangititis patients present with?

Upper and lower airway problems
Abnormal CXR
Microscopic hematuria

25

GWPA labs show up as?

Asthma ad lung disease ANCA +
Granulomatus inflammation

26

What does Eosinophilic granulomatosis with polyangiitis present as?

Asthma and lung disease
Upper airway and ear disease
Tender subcutaneous nodules
Heart failure
Thromboembolic disease
Mononeuritis multiplex

27

Labs for EGWP?

40-60% ANCA
5000-9000 Eosinophil
Nondestruction infiltration of vessel walls by eosinophils

28

Treatment for EGWP?

Corticosteroids, immunosuppressants

29

Types of immune complex small vessel vasculitis?

Antiglomerular Basement Membrane Disease
Cryoglobulinemic Vasculitis
IgA associated Vasculitis
Hypocomplementemic Urticarial vasculitis

30

What does ABMD cause?

Glomerulonephritis
Pulmonary hemorrhage
Death in untreated

31

Diagnosis for ABMD?

Kidney biopsy
Anti GBM antibodies
Positive ANCA

32

Treatment for ABMD?

Plasmapheresis combined with prednisone and cyclophosphamide