Flashcards in Vasculitis Deck (32):
Vasculitis can lead to what?
Necrosis of vessel wall with perforation and hemorrhage into adjacent tissues. Occlusion of vessel can lead to distal ischemia and infarction of tissue
What organisms can cause infectious vasculitis?
Rickettsia, Syphilis, Aspergillus
What can cause noninfectious vasculitis?
Autoimmune response to known pathogen such as Cryoglobulinemic vasculitis and Hep C infection
Types of large vessel vasculitis (2)?
Giant Cell Arteritis
Who does Takayasu present in?
Younger patients with clarification of extremities
Telltale sign of Takayasu?
BP diff between extremities, bruit over subclavian artery/aorta
Treatment of Takayasu?
High dose corticosteroids
Giant cell arteritis presents in who?
Older patients > 50 with headache, visual loss, jaw claudication
Major worry from Giant cell arteritis?
Gold standard of diagnosis for GCA?
Temporal artery biopsy
Treatment for GCA?
High dose corticosteroid
GCA associated with what other disease?
What is Polymyalgia Rheumatica?
Sudden onset of pain and stiffness in shoulders and hips in people > 50 with high ESR
Types of Medium Vessel Vasculitis? 2
Polyarteritis Nodosum (PAN) most commonly involved organ?
Kidney with Elevated BUN/Creatinine and Elevated BP
Treatment for PAN?
High dose corticosteroids, Cyclophophamide, plasmapheresis
Who does Kawasaki disease occur in?
Childhood disease, but can occur in adults
What can Kawasaski disease lead to?
Coronary artery aneurysms, depressed myocardial contractility, heart failure, myocardial infarction, arrhythmia, and peripheral arterial occlusion.
Treatment for Kawasaki?
IVIG within first 10 days
What Small vessel vasculitis are there? (3)
Granulomatosis with polyangitis
Eosinophillic granulomatosis with polyangitis
What does ANCA stand for?
Antibodies against Neutrophil Cytoplasmic Antigens
What does Microscopic polyangiitis affect?
Lungs and Kidneys
Lab work for Microscopic polyangiitis shows up as?
Renal biopsy shows not granulomatous inflammation
In Granulomatosis with polyangititis patients present with?
Upper and lower airway problems
GWPA labs show up as?
Asthma ad lung disease ANCA +
What does Eosinophilic granulomatosis with polyangiitis present as?
Asthma and lung disease
Upper airway and ear disease
Tender subcutaneous nodules
Labs for EGWP?
Nondestruction infiltration of vessel walls by eosinophils
Treatment for EGWP?
Types of immune complex small vessel vasculitis?
Antiglomerular Basement Membrane Disease
IgA associated Vasculitis
Hypocomplementemic Urticarial vasculitis
What does ABMD cause?
Death in untreated
Diagnosis for ABMD?
Anti GBM antibodies