Skin

Question 1

Which layer of the skin contains desmosomes?

Answer 1

stratum spinosum

Question 2

What type of hypersensitivity is Atopic Dermatitis?

Answer 2

type one

Question 3

What type of hypersensitivity is Contact Dermatitis?

Answer 3

four

Question 4

What is the main bacteria of acne?

Answer 4

Propionibacterium acnes

Question 5

What enzyme is possessed by Propionibacterium acnes ?

Answer 5

lipases

Question 6

What does these lipases do?

Answer 6

release pro-inflammatory fatty acids

Question 7

What causes psoriasis?

Answer 7

excessive keratinocyte production

Question 8

Which haplotype is associated with Psoriasis?

Answer 8

HLA-C

Question 9

What is parakeratosis?

Answer 9

hyperkeratosis with retention of keratinocyte nuclei in stratum corneum

Question 10

What is Auspitz Sign?

Answer 10

thinning of epidermis and elongated dermal papillae that results in “pinpoint” bleeding when scab is picked off

Question 11

What are the three most common locations for Lichen Planus?

Answer 11

wrists/elbows/oral mucosa

Question 12

What does histology during lichen planus show?

Answer 12

inflammation of dermal/epidermal junction

Question 13

What infection may lichen planus be associated with?

Answer 13

chronic HCV

Question 14

What structure is attacked during pemphigus vulgaris? Between what specific layer?

Answer 14

autoimmune destruction of desmosomes between

stratum spinosum

Question 15

What specific protein is targeted during Pemphigus Vulgaris?

Answer 15

Desmoglein

Question 16

What type of immunoglobulin is responsible for pemphigus vulgaris?

Answer 16

IgG

Question 17

What specific layer of the epidermis is held together by desmosomes?

Answer 17

stratum spinosum

Question 18

Does the stratum basale remain attached to the dermis during pemphigus vulgaris? Via what protein?

Answer 18

yes

hemidesmosome

Question 19

Does pemphigus vulgaris or bullous pemphigoid rupture easily?

Answer 19

pemphigus vulgaris

Question 20

Which protein is targeted during Bullous Pemphigoid?

Answer 20

hemidesmosomes

Question 21

Which two structures are normally connected by hemidesmosomes?

Answer 21

stratum basale and underlying dermis

Question 22

In what two locations does pemhigus vulgaris present?

Answer 22

skin and oral mucosa

Question 23

In what two locations does bullous pemphigoid present?

Answer 23

skin

Question 24

Which immunoglobulin is present during bullous pemphigoid?

Answer 24

IgG

Question 25

Do bullous pemphigoid rupture easily?

Answer 25

no

Question 26

What are Munro abscesses?

Answer 26

neutrophils in stratum corneum

Question 27

Where does IgA deposit in the skin during Dermatitis Herpetiformis?

Answer 27

tips of dermal papillae

Question 28

What two infections can cause Erythema Multiforme?

Answer 28

HSV and Mycoplasma

Question 29

What two drugs are known to cause erythema multiforme?

Answer 29

penicillin and sulfonamides

Question 30

What cell proliferates during Seborrheic Keratosis?

Answer 30

squamous

Question 31

What form of UV light causes BCC?

Answer 31

UVB

Question 32

Which skin carcinoma features telangiectasia?

Answer 32

BCC

Question 33

Actinic keratosis is a precursor lesion for which skin carcinoma?

Answer 33

SCC

Question 34

Arsenic exposure is a risk factor for what skin carcinoma?

Answer 34

SCC

Question 35

Immunosuppressive therapy is a risk factor for what skin carcinoma?

Answer 35

SCC

Question 36

What cells are melanocytes derived from?

Answer 36

neural crest

Question 37

Which layer of the skin are melanocytes present in?

Answer 37

basal

Question 38

What enzyme is missing during Albinism?

Answer 38

Tyrosinase

Question 39

Which increases in a freckle?

Answer 39

Melanosome

Question 40

What cell proliferates during a mole?

Answer 40

melanocyte

Question 41

Which two bacteria give rise to impetigo?

Answer 41

S. aureus S. pyogenes

Question 42

Which two bacteria give rise to cellulitis?

Answer 42

S. aureus S. pyogenes

Question 43

Staphylococcal scalded skin syndrome effects which layer of the epidermis?

Answer 43

Stratum granulosum

Question 44

Where does the separation of the skin occur durin Toxic Epidermal Necrolysis?

Answer 44

Dermal-Epidermal

Question 45

Molloscum Contagiosum is caused by what virus?

Answer 45

Pox

Question 46

What is thought to be the cause of psoriasis?

Answer 46

trauma

Question 47

What are the two treatments of psoriasis?

Answer 47

glucocorticoids UVA light with psoralen

Question 48

What is the severe form of Erythema Multiforme?

Answer 48

Toxic Epidermal Necrolysis

Question 49

What two places does Acanthosis Nigricans arise?

Answer 49

Axilla and Groin

Question 50

Which form of skin carcinoma features peripheral palisading nuclei?

Answer 50

BCC

Question 51

Chronic inflammation can lead to what skin carcinoma?

Answer 51

SCC

Question 52

What is keratoacanthoma?

Answer 52

well-differentiated squamous cell carcinoma

Question 53

What does keratoacanthoma do?

Answer 53

develop and regress rapidly

Question 54

Where structure melanin synthesized in?

Answer 54

melanosomes

Question 55

Where does a junctional nevus from? Children or adults?

Answer 55

dermal-epidermal junction children

Question 56

What is the most common mole in adults?

Answer 56

intradermal

Question 57

Where does acral lentiginous melanoma occur?

Answer 57

palms and soles

Question 58

What type of melanoma arises in dark-skinned individuals?

Answer 58

acral lentignous

Question 59

Which form of melanoma is not related to sunlight exposure?

Answer 59

acral lentiginous

Question 60

Why is Vitamin A used to treat acne?

Answer 60

to prevent keratin production

Question 61

What type of surfaces is psoriasis on?

Answer 61

extensor

Question 62

What undergoes hyperplasia during acanthosis?

Answer 62

epidermis

Question 63

'Saw-tooth' pattern refers to the histology of what disease?

Answer 63

Lichen Planus

Question 64

Which autoimmune disease can cause Erythema Multiforme?

Answer 64

SLE

Question 65

Keratin pseudocysts on histology are indicative of what disease?

Answer 65

Seborrheic Keratosis

Question 66

Peripheral Palisading on histology is indicative of what disease?

Answer 66

Basal cell carcinoma

Question 67

What syndrome can progress to melanoma?

Answer 67

Dysplastic nevus syndrome

Question 68

Which skin disease presents with elongation of Dermal Papillae?

Answer 68

psoriasis

Question 69

Where does Lichen Planus display inflammation?

Answer 69

dermal-epidermal junction

Question 70

Which autoimmune disease can produce Erythema Multiforme?

Answer 70

SLE

Question 71

What two characteristics are needed to called Erythema Multiforme Steven Johnsons Syndrome?

Answer 71

fever lip/oral mucosa involvement

Question 72

Is a draining sinus tract squamous or basal cell carcinoma?

Answer 72

squamous

Question 73

Freckles have an increase in what structure?

Answer 73

melanosomes

Question 74

What is a compound nevus?

Answer 74

nevus that extends into dermis

Question 75

What drug can cause contact dermatitis?

Answer 75

penicillin

Question 76

What does psoriasis do to the nails?

Answer 76

pitting

Question 77

Regarding BCC, what does palisading mean?

Answer 77

cells line up around edge

Question 78

Draining sinus tract is associated with what skin cancer?

Answer 78

SCC

Question 79

Via what structure does a keratoacanthoma present?

Answer 79

cup filled tumor with keratin debris

Question 80

Is vitiligo caused by destruction of melanocytes or melanosomes?

Answer 80

melanocytes

Question 81

What type of nevi would an adult develop?

Answer 81

intra-dermal

Question 82

What two structures does cellulitis penetrate into?

Answer 82

dermal or subcutaneously