Flashcards in Skin Deck (82)
Which layer of the skin contains desmosomes?
What type of hypersensitivity is Atopic Dermatitis?
What type of hypersensitivity is Contact Dermatitis?
What is the main bacteria of acne?
What enzyme is possessed by Propionibacterium acnes ?
What does these lipases do?
release pro-inflammatory fatty acids
What causes psoriasis?
excessive keratinocyte production
Which haplotype is associated with Psoriasis?
What is parakeratosis?
hyperkeratosis with retention of keratinocyte nuclei in stratum corneum
What is Auspitz Sign?
thinning of epidermis and elongated dermal papillae that results in "pinpoint" bleeding when scab is picked off
What are the three most common locations for Lichen Planus?
What does histology during lichen planus show?
inflammation of dermal/epidermal junction
What infection may lichen planus be associated with?
What structure is attacked during pemphigus vulgaris? Between what specific layer?
autoimmune destruction of desmosomes between
What specific protein is targeted during Pemphigus Vulgaris?
What type of immunoglobulin is responsible for pemphigus vulgaris?
What specific layer of the epidermis is held together by desmosomes?
Does the stratum basale remain attached to the dermis during pemphigus vulgaris? Via what protein?
Does pemphigus vulgaris or bullous pemphigoid rupture easily?
Which protein is targeted during Bullous Pemphigoid?
Which two structures are normally connected by hemidesmosomes?
stratum basale and underlying dermis
In what two locations does pemhigus vulgaris present?
skin and oral mucosa
In what two locations does bullous pemphigoid present?
Which immunoglobulin is present during bullous pemphigoid?
Do bullous pemphigoid rupture easily?
What are Munro abscesses?
neutrophils in stratum corneum
Where does IgA deposit in the skin during Dermatitis Herpetiformis?
tips of dermal papillae
What two infections can cause Erythema Multiforme?
HSV and Mycoplasma
What two drugs are known to cause erythema multiforme?
penicillin and sulfonamides
What cell proliferates during Seborrheic Keratosis?
What form of UV light causes BCC?
Which skin carcinoma features telangiectasia?
Actinic keratosis is a precursor lesion for which skin carcinoma?
Arsenic exposure is a risk factor for what skin carcinoma?
Immunosuppressive therapy is a risk factor for what skin carcinoma?
What cells are melanocytes derived from?
Which layer of the skin are melanocytes present in?
What enzyme is missing during Albinism?
Which increases in a freckle?
What cell proliferates during a mole?
Which two bacteria give rise to impetigo?
Which two bacteria give rise to cellulitis?
Staphylococcal scalded skin syndrome effects which layer of the epidermis?
Where does the separation of the skin occur durin Toxic Epidermal Necrolysis?
Molloscum Contagiosum is caused by what virus?
What is thought to be the cause of psoriasis?
What are the two treatments of psoriasis?
UVA light with psoralen
What is the severe form of Erythema Multiforme?
Toxic Epidermal Necrolysis
What two places does Acanthosis Nigricans arise?
Axilla and Groin
Which form of skin carcinoma features peripheral palisading nuclei?
Chronic inflammation can lead to what skin carcinoma?
What is keratoacanthoma?
well-differentiated squamous cell carcinoma
What does keratoacanthoma do?
develop and regress rapidly
Where structure melanin synthesized in?
Where does a junctional nevus from? Children or adults?
What is the most common mole in adults?
Where does acral lentiginous melanoma occur?
palms and soles
What type of melanoma arises in dark-skinned individuals?
Which form of melanoma is not related to sunlight exposure?
Why is Vitamin A used to treat acne?
to prevent keratin production
What type of surfaces is psoriasis on?
What undergoes hyperplasia during acanthosis?
'Saw-tooth' pattern refers to the histology of what disease?
Which autoimmune disease can cause Erythema Multiforme?
Keratin pseudocysts on histology are indicative of what disease?
Peripheral Palisading on histology is indicative of what disease?
Basal cell carcinoma
What syndrome can progress to melanoma?
Dysplastic nevus syndrome
Which skin disease presents with elongation of Dermal Papillae?
Where does Lichen Planus display inflammation?
Which autoimmune disease can produce Erythema Multiforme?
What two characteristics are needed to called Erythema Multiforme Steven Johnsons Syndrome?
lip/oral mucosa involvement
Is a draining sinus tract squamous or basal cell carcinoma?
Freckles have an increase in what structure?
What is a compound nevus?
nevus that extends into dermis
What drug can cause contact dermatitis?
What does psoriasis do to the nails?
Regarding BCC, what does palisading mean?
cells line up around edge
Draining sinus tract is associated with what skin cancer?
Via what structure does a keratoacanthoma present?
cup filled tumor with keratin debris
Is vitiligo caused by destruction of melanocytes or melanosomes?
What type of nevi would an adult develop?