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Flashcards in Skin Deck (82)
1

Which layer of the skin contains desmosomes?

stratum spinosum

2

What type of hypersensitivity is Atopic Dermatitis?

type one

3

What type of hypersensitivity is Contact Dermatitis?

four

4

What is the main bacteria of acne?

Propionibacterium acnes

5

What enzyme is possessed by Propionibacterium acnes ?

lipases

6

What does these lipases do?

release pro-inflammatory fatty acids

7

What causes psoriasis?

excessive keratinocyte production

8

Which haplotype is associated with Psoriasis?

HLA-C

9

What is parakeratosis?

hyperkeratosis with retention of keratinocyte nuclei in stratum corneum

10

What is Auspitz Sign?

thinning of epidermis and elongated dermal papillae that results in "pinpoint" bleeding when scab is picked off

11

What are the three most common locations for Lichen Planus?

wrists/elbows/oral mucosa

12

What does histology during lichen planus show?

inflammation of dermal/epidermal junction

13

What infection may lichen planus be associated with?

chronic HCV

14

What structure is attacked during pemphigus vulgaris? Between what specific layer?

autoimmune destruction of desmosomes between

stratum spinosum

15

What specific protein is targeted during Pemphigus Vulgaris?

Desmoglein

16

What type of immunoglobulin is responsible for pemphigus vulgaris?

IgG

17

What specific layer of the epidermis is held together by desmosomes?

stratum spinosum

18

Does the stratum basale remain attached to the dermis during pemphigus vulgaris? Via what protein?

yes

hemidesmosome

19

Does pemphigus vulgaris or bullous pemphigoid rupture easily?

pemphigus vulgaris

20

Which protein is targeted during Bullous Pemphigoid?

hemidesmosomes

21

Which two structures are normally connected by hemidesmosomes?

stratum basale and underlying dermis

22

In what two locations does pemhigus vulgaris present?

skin and oral mucosa

23

In what two locations does bullous pemphigoid present?

skin

24

Which immunoglobulin is present during bullous pemphigoid?

IgG

25

Do bullous pemphigoid rupture easily?

no

26

What are Munro abscesses?

neutrophils in stratum corneum

27

Where does IgA deposit in the skin during Dermatitis Herpetiformis?

tips of dermal papillae

28

What two infections can cause Erythema Multiforme?

HSV and Mycoplasma

29

What two drugs are known to cause erythema multiforme?

penicillin and sulfonamides

30

What cell proliferates during Seborrheic Keratosis?

squamous

31

What form of UV light causes BCC?

UVB

32

Which skin carcinoma features telangiectasia?

BCC

33

Actinic keratosis is a precursor lesion for which skin carcinoma?

SCC

34

Arsenic exposure is a risk factor for what skin carcinoma?

SCC

35

Immunosuppressive therapy is a risk factor for what skin carcinoma?

SCC

36

What cells are melanocytes derived from?

neural crest

37

Which layer of the skin are melanocytes present in?

basal

38

What enzyme is missing during Albinism?

Tyrosinase

39

Which increases in a freckle?

Melanosome

40

What cell proliferates during a mole?

melanocyte

41

Which two bacteria give rise to impetigo?

S. aureus

S. pyogenes

42

Which two bacteria give rise to cellulitis?

S. aureus

S. pyogenes

43

Staphylococcal scalded skin syndrome effects which layer of the epidermis?

Stratum granulosum

44

Where does the separation of the skin occur durin Toxic Epidermal Necrolysis?

Dermal-Epidermal

45

Molloscum Contagiosum is caused by what virus?

Pox

46

What is thought to be the cause of psoriasis?

trauma

47

What are the two treatments of psoriasis?

glucocorticoids

UVA light with psoralen

48

What is the severe form of Erythema Multiforme?

Toxic Epidermal Necrolysis

49

What two places does Acanthosis Nigricans arise?

Axilla and Groin

50

Which form of skin carcinoma features peripheral palisading nuclei?

BCC

51

Chronic inflammation can lead to what skin carcinoma?

SCC

52

What is keratoacanthoma?

well-differentiated squamous cell carcinoma

53

What does keratoacanthoma do?

develop and regress rapidly

54

Where structure melanin synthesized in?

melanosomes

55

Where does a junctional nevus from? Children or adults?

dermal-epidermal junction

children

56

What is the most common mole in adults?

intradermal

57

Where does acral lentiginous melanoma occur?

palms and soles

58

What type of melanoma arises in dark-skinned individuals?

acral lentignous

59

Which form of melanoma is not related to sunlight exposure?

acral lentiginous

60

Why is Vitamin A used to treat acne?

to prevent keratin production

61

What type of surfaces is psoriasis on?

extensor

62

What undergoes hyperplasia during acanthosis?

epidermis

63

'Saw-tooth' pattern refers to the histology of what disease?

Lichen Planus

64

Which autoimmune disease can cause Erythema Multiforme?

SLE

65

Keratin pseudocysts on histology are indicative of what disease?

Seborrheic Keratosis

66

Peripheral Palisading on histology is indicative of what disease?

Basal cell carcinoma

67

What syndrome can progress to melanoma?

Dysplastic nevus syndrome

68

Which skin disease presents with elongation of Dermal Papillae?

psoriasis

69

Where does Lichen Planus display inflammation?

dermal-epidermal junction

70

Which autoimmune disease can produce Erythema Multiforme?

SLE

71

What two characteristics are needed to called Erythema Multiforme Steven Johnsons Syndrome?

fever

lip/oral mucosa involvement

72

Is a draining sinus tract squamous or basal cell carcinoma?

squamous

73

Freckles have an increase in what structure?

melanosomes

74

What is a compound nevus?

nevus that extends into dermis

75

What drug can cause contact dermatitis?

penicillin

76

What does psoriasis do to the nails?

pitting

77

Regarding BCC, what does palisading mean?

cells line up around edge

78

Draining sinus tract is associated with what skin cancer?

SCC

79

Via what structure does a keratoacanthoma present?

cup filled tumor with keratin debris

80

Is vitiligo caused by destruction of melanocytes or melanosomes?

melanocytes

81

What type of nevi would an adult develop?

intra-dermal

82

What two structures does cellulitis penetrate into?

dermal or subcutaneously