Spleen Flashcards Preview

Anatomic pathology > Spleen > Flashcards

Flashcards in Spleen Deck (256)
Loading flashcards...
1

Splenomegaly associated with systemic lupus erythematosus or with rheumatoid arthritis: Other findings (2).

Neutropenia.

Leg ulcers.

2

Reactive lymphoid hyperplasia without germinal centers: Cells (3).

Heterogeneous population of lymphocytes.

Immunoblasts.

Tingible-body macrophages.

3

Reactive lymphoid hyperplasia without germinal centers: Locations of infiltrate.

White pulp, including the periarteriolar lymphoid sheaths.

Infiltration of the trabeculae may lead to splenic rupture.

4

Castleman's disease of the spleen: Most common type.

Plasma-cell type.

The hyaline-vascular type rarely or never occurs.

5

Castleman's disease of the spleen: Types of multicentric disease.

Plasma-cell type.

Plasmablastic type.

6

Reactive follicular hyperplasia with formation of germinal centers: Gross pathology.

Nodularity of white pulp.

7

Castleman's disease of the spleen: Histology of the plasma-cell type (2).

Hyperplastic or regressively transformed follicles.

Many plasma cells in the red pulp.

8

Castleman's disease of the spleen: Histology of the plasmablastic type.

Fibrosis and many plasma cells surround hyperplastic or regressively transformed follicles.

Unremarkable red pulp.

Mantle zones contain immunoblastoid and plasmablastoid cells.

9

Castleman's disease of the spleen: Microlymphoma.

Aggregates of HHV8-positive plasmablasts.

10

Castleman's disease of the spleen: Immunophenotype of plasmablasts (4,1).

Positive: CD20, IgM, lambda light chain, HHV8.

Negative: CD30.

11

Castleman's disease of the spleen: Laboratory finding associated with multicentric disease.

Increased IL-6 in the serum.

12

Castleman's disease of the spleen: Complication of the plasmablastic type.

Development of plasmablastic lymphoma.

13

Common variable immunodeficiency: Gross appearance of spleen.

May be enlarged or unremarkable.

14

Common variable immunodeficiency: Histology of splenic follicles

May be atrophic, hyperplastic, or normal.

May exhibit atypical follicular hyperplasia.

15

Common variable immunodeficiency: Other possible histologic features (3).

Granulomas.

Immunoblasts and Reed-Sternberg-like cells.

Lymphoid hyperplasia in the red pulp.

16

Common variable immunodeficiency: Viral association.

In most cases, EBV is detectable by

- Immunohistochemical stain for LMP.
- In-situ hybridization for EBV (EBER).

17

Common variable immunodeficiency: Lymphocytes.

Mixture of T cells and B cells.

18

Common variable immunodeficiency vs. lymphoma (2).

Lymphoma:

- (Usually) no established history of immunodeficiency.
- Demonstrated clonality.

19

Castleman's disease of the spleen: Viral associations of plasmablastic type.

HHV8, with or without HIV.

20

Autoimmune lymphoproliferative syndrome: Presentation.

Generalized lymphadenopathy, splenomegaly, and autoimmune disease in a child under 2 years of age.

21

Autoimmune lymphoproliferative syndrome: Aetiology.

Mutation in Fas, Fas ligand, caspase 8, or caspase 10.

22

Autoimmune lymphoproliferative syndrome: Manifestation in peripheral blood.

Autoimmune cytopenias.

23

Autoimmune lymphoproliferative syndrome: Complication.

Hodgkin's lymphoma or non-Hodgkin's lymphoma.

24

Autoimmune lymphoproliferative syndrome: Histology (3).

White pulp: Follicular hyperplasia, expansion of germinal centers.

Red pulp: Expansion by T cells and plasma cells.

PALS: Same as for red pulp.

25

Autoimmune lymphoproliferative syndrome: Immunohistochemistry (2).

Double-negative T lymphocytes, mainly in the red pulp.

No expression of CD25.

26

Splenic marginal-zone lymphoma: Typical presentation.

Massive splenomegaly.

27

Splenic marginal-zone lymphoma: Manifestations in peripheral blood (2).

Autoimmune anaemia.

Thrombocytopenia.

28

Splenic marginal-zone lymphoma: Additional possible laboratory findings (2).

Monoclonal IgM or IgD.

Cryoglobulinemia.

29

Splenic marginal-zone lymphoma: Affected organs.

Splenic hilar lymph nodes, peripheral blood, bone marrow, and liver may all be involved at presentation.

Peripheral lymph nodes are not affected.

30

Splenic marginal-zone lymphoma: Infectious association.

Hepatitis C.