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Flashcards in Liver Deck (241)
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Acute viral hepatitis: Type and location of inflammation.

Mainly lymphocytic; zone 3.

1

Acute viral hepatitis: Changes in hepatocytes (3).

Swollen hepatocytes with rarified and granular cytoplasm.

Apoptotic bodies.

Replacement of lost hepatocytes by small clusters of lymphocytes and macrophages.

2

Acute hepatitis B: Classic histologic finding.

"Ground glass" hepatocytes.

3

Chronic viral hepatitis: Definition.

Persistent liver injury with positive viral serology and high serum aminotransferases for more than 6 months.

4

Chronic viral hepatitis: Location of inflammation.

Portal and periportal regions.

5

Characteristic features of ___.

A. Chronic hepatitis B.
B. Chronic hepatitis C (3).

A. Ground-glass hepatocytes.

B. Lymphoid aggregates, mild macrovesicular steatosis, damaged interlobular bile ducts.

6

Epstein-Barr viral hepatitis: Histology (2).

Single-file arrangement in lymphocytes and plasma cells in sinusoids.

Marked regeneration of hepatocytes.

7

Bacterial abscesses of the liver: Agents (3).

Staphylococcus aureus.

Salmonella typhi.

Treponema pallidum.

8

Syphilis of the liver: Gross lesions (2).

Gummata.

Hepar lobatum.

9

Syphilis of the liver: Histopathology.

Gummata are granulomatous abscesses that heal as dense scars.

10

Echinococcal infection of the liver: Local complication.

Secondary cholangitis.

11

Malaria of the liver: Histopathology (2).

Hyperplasia of Küpffer cells.

Phagocytosis of ruptured erythrocytes.

12

Hepatic leishmaniasis: Histopathology (2).

Hyperplasia of Küpffer cells.

Phagocytosis of organisms (Donovan bodies).

13

Hepatic leishmaniasis: Best special stain.

Giemsa.

14

Acetaminophen toxicity: Histopathology.

Hepatocellular necrosis in zone 3.

15

Drugs that cause a pattern mimicking acute viral hepatitis (3).

Antituberculosis drugs.

Anesthetics.

Aspirin (NSAIDs).

16

Drug that causes cholestasis with loss of bile ducts.

Augmentin (amoxicillin + clavulanic acid).

17

Drugs that cause the pattern of "vanishing bile ducts" (4).

Chlorpromazine.

Haloperidol.

Amoxicillin.

Flucloxacllin.

18

Drugs that cause microvesicular steatosis (4).

Valproic acid.

Tetracycline.

Nucleoside analogs.

Aspirin (Reye's syndrome).

19

Drugs that cause veno-occlusive disease (2).

Pyrrholizidine alkaloids.

Chemotherapeutic agents.

20

Drugs that cause a steatohepatitis-like pattern (2).

Amiodarone.

Tamoxifen.

21

Hypervitaminosis A: Histopathology (2).

Hypertrophy of stellate cells.

Pericellular and perivenular fibrosis.

22

Histopathologic clues that drugs may be responsible for liver disease (3).

Many eosinophils.

Epithelioid granulomas.

Hepatitis together with cholestasis.

23

Alcoholic hepatitis: Location of histologic changes.

Zone 3.

24

Alcoholic hepatitis: Main histologic changes (5).

Steatosis.

Ballooning degeneration.

Lobular inflammatory infiltrates containing neutrophils.

Mallory bodies.

Peri cellular and perivenular ("chicken-wire") fibrosis.

25

Alcoholic hepatitis vs. viral hepatitis: Location of inflammation.

Alcoholic: Mostly lobular.

Chronic viral: Mostly portal and periportal.

26

Ascariasis of the liver: Gross appearance.

Numerous foul-smelling cavities.

27

Alcoholic hepatitis vs. non-alcoholic steatohepatitis (2).

NASH:

− More glycogen aged nuclei.
− No sclerosing hyaline necrosis.

28

Non-alcoholic steatohepatitis: Risk factors (4).

Central obesity.

Insulin resistance / diabetes mellitus, type II.

Arterial hypertension.

Hypertriglyceridemia.

29

Mallory body: Composition.

Cytoskeletal intermediate filaments associated with ubiquitin.