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Flashcards in Spleen Deck (12)
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What is the difference between splenomegaly and hypersplenism?

Hypersplenism is just one cause of splenomegaly. Hypersplenism is when there is increased destruction of RBCs by spleen


Primary hypersplenism

Idiopathic. Very rare. Diagnosis of exclusion. Seen in women more


Causes of secondary hypersplenism

Hemolytic anemia, neoplasms (leukemia, lymphoma, metastatic carcinoma), myelodysplastic syndromes, chronic inflammatory disease (Felty syndrome, sarcoidosis, SLE), congestive splenomegaly (portal HTN, cirrhosis, portal or splenic vein obstruction, severe CHF), infection, metabolic or storage diseases (eg amyloid, niemann pick)


Treatment of hypersplenism

Primary: must get splenectomy. Secondary might need is depending on how much it is affecting patient.

If get splenectomy, must get Pneumococcal, Hib, and meningococcus vaccines



Spleen is anatomically present but not functional. Results in increased risk of infection particularly with encapsulated organisms.


Causes of hyposplenism

Sickle cell disease, IBD, collagen vascular disease, autoimmune.


What does the peripheral smear look likening hyposplenism?

Howell-Jolly bodies (basophilic nuclear remnants in circulating RBCs), Heinz bodies (inclusions of denatured Hg), acanthocytes (spur cells)


Review leukemia and lymphoma flashcards in medicine section

Cool beans


Review pathophys of TTP

vWF is abnormal, in multimers, due to ADAMTS13 deficiency. These multimers attract platelets to site of clot but cause abnormal clumping. This leads to obstruction and shearing of RBCs in microvasculature.


Pentad to TTP

Fever, anemia, thrombocytopenia, renal failure, neurological sx (may have waxing and waning mental status)


Causes of TTP

Infection (HIV, E. coli), malignancy, pregnancy, drugs, autoimmune disorders


Where is spleen located?

LUQ between ribs 8 and 11