stable coronary artery disease Flashcards

1
Q

what percent of the ciruclatrion ins the heart is microcirculation

A

70%

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2
Q

what is coronary artery diseae

A

angina and mi

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3
Q

what is stable atypical angina sympotns

A

breathlessness without cest pain, burn/ refulx/ burpig

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4
Q

main gender effected by angia

A

males

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5
Q

what are the determines of heart demand for blood to heart iee. when does the heart use up more 02

A

heart reaet
systolic blood pressure
myocardil wlal stress
myocardil contraciles

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6
Q

what are the determeis of heart supley ie when does the heart reci e less o2

A

coronary heart diames
collateral blood flow
perfusion pressure
heart

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7
Q

what ist he order for treating stable coraonery artyr dise

A

1 - relive sympons by reducing worklo and improin flow
2- halt/ slow disease
3 - prevent mi
4 - prevent premature death

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8
Q

what are the pharmacotherapy rate limitins drugs

A

beat adrenoreceptor antagonists
calcium channel blockers
ivabradine channels

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9
Q

what are the vaso dilator drugs

A

nitrates - e.g. nitric oxide
calciium channel blockers
potassium channel activators

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10
Q

what are exampesl of sodium chanel activators

A

ranolazine

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11
Q

what are examplesof antiplatelets

A

aspirin, clopidogrel, ticagrelor prasugrel

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12
Q

what are some exaples of cholesetor lowering drugs

A

hmg- coa reductas inhibitors
fibrates
pcsk- 9 inhibitors

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13
Q

examples of cardio selctive betal blocker

A

bisoprolol, metoprolo - short acting
atenolol

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14
Q

what are some examples of non selective beta blockers

A

carvedilol, propranolol

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15
Q

what are some side effects of beta blokcer

A

asthma, periperva vasucalr disaer, raynaulds syndorem, acute herat faiule, bradycarida, fatique

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16
Q

what is the effect of beta antangoins on systolic wall tneoin

A

reduced, thus more relaxed

17
Q

what are rate liming calcium channel blokcer caled

A

non diphyropyridine

18
Q

what aer the moslt vasodilating calcium channel blocekrs called

A

dihyropyridine

19
Q

exampels of non dihydropyridine calcium chanel blocker

A

amlodipine, felodipine, nifedipine

20
Q

what are examples of some dihydropyridine calcium channel blocker

A

verapamil
dilitazem

21
Q

what are side effects of calcium channel blocker

A

bradycardia, reduced lv fuction, headaches, flusihg, preipheal odema, hypotension

22
Q

wha are potasium vaso dilators exMPELS

A

NICRORANDIL

23
Q

WHAT ARE THE SIDE EFFECTS OF NICORANDIL

A

GI ulcers, hypotension

24
Q

how do postiaium chennl activtor work

A

inhibi claium influx thus caus vasodilators

25
Q

What heart rate do funncy chnel inhibirots wok on

A

sinus heart rate

26
Q

what is a funny channel inhibitor example

A

ivabradine

27
Q

what is the side effects of ivabradin

A

bradycarida, sa node diase

28
Q

what are some thromboxane a2 inhibots work on

A

txa2 pathway by prevent the sytehis of cox and plteulet activation

29
Q

what does theinioprides work on

A

p2y12 recectors

30
Q

what are exapesl of p2y12 inhitors

A

clopidogrel, ticagreol, prasugrel

31
Q

what re exaples of thromboaxan a2 ihibotrs

A

aspirin

32
Q

what is the effect of ranolazine

A

late sodium chanel inhibort in myocadiul cells, thu ibhore radi phase of delated calcium reducin interacelluar alium

33
Q

what s the side effects of ranolazine

A

prologned qtc - wave

34
Q

what drug should soium channle blocker be avoided using with

A

cyp enzyme inbibtitos

35
Q
A