STDs 2

Question 0

HPV tumors have a ___ survival rate that alcohol and tobacco related tumors

Answer 0

better

Question 1

since 2006, oral pharynx cancer has been increasing, primarily in ___

Answer 1

men

Question 2

the better survival rate for HPV tumors is probably because:

Answer 2

the cancer is expressing antigens that are not normally found in the host

Question 3

in the malignant progression of HPV, the viral genome integrates into the host chromosomes, knocking out ___, a viral repressor protein, allowing increased ___ expression

Answer 3

E2, E6/E7

Question 4

In CIN I, ___ of the epithelium is dysplastic

Answer 4

1/3rd

Question 5

In CIN II, ___ of the epithelium is dysplastic

Answer 5

2/3rds

Question 6

In CIN III, ___ of the epithelium is dysplastic

Answer 6

all

Question 7

where does dysplasia occur most frequently in the cervix?

Answer 7

transformation/ junctional zone

Question 8

why does infection occur in the transformation zone?

Answer 8

probably because the HPV targets stem-like cells in that region

Question 9

__% of cervical cancers are due to HPV 16

Answer 9

60

Question 10

__% of cervical cancers are due to HPV 18

Answer 10

15

Question 11

if you have CIN I, ___% will regress on their own. This ___ as you go to CIN II and CIN III

Answer 11

57%, decreases

Question 12

The pap smear has __ sensitivity but ___ specificity

Answer 12

low, high

Question 13

colposcopy

Answer 13

if pap smear is positive, identifies the lesions that should be biopsied

Question 14

you can get up to 100% sensitivity for HPV by using ___

Answer 14

Hybrid capture

Question 15

hybrid capture is usually used starting around age ___ because ___

Answer 15

30, most HPV infections will clear on their own

Question 16

treatment of external HPV lesions:

Answer 16

salicylic acid
mitotic inhibitors
5-fluorouracil
cryotherapy
excision

Question 17

therapy for vaginal or cervical HPV infections:

Answer 17

ablative
excision
pharmaceutical

Question 18

ablative techniques

Answer 18

• cryotherapy

- laser vaporization therapy

Question 19

excision techniques

Answer 19

conization- a cone of tissue is excised for further examination and/or remove a lesion
LEEP- an electrical wire to cauterize

Question 20

pharmaceutical treatments

Answer 20

lesions recur following withdrawal, not treatment of choice

Question 21

when L1 is expressed:

Answer 21

it assembles itself, forming pentamers that recognizes themselves and form virus-like particles