STEP 2: AUTOIMMUNE Flashcards
(12 cards)
What is Felty syndrome?
A severe subtype of RA characterized by neutropenia and splenomegaly.
RA stands for rheumatoid arthritis.
What percentage of patients with RA are affected by Felty syndrome?
1–3% of patients with RA.
This indicates that Felty syndrome is rare.
What are the components of the clinical triad associated with Felty syndrome?
- Arthritis
- Splenomegaly
- Neutropenia
The triad is critical for diagnosis.
What are some other clinical features of Felty syndrome?
- Skin ulcers of the lower limbs
- Hepatomegaly
- Fever
- Chest pain
Chest pain may indicate pleuritis or pericarditis.
What is Felty syndrome associated with regarding cancer risk?
Increased risk of non-Hodgkin lymphoma.
This association is important for monitoring patients.
What laboratory findings are indicative of Felty syndrome?
- Leukopenia with selective neutropenia
- ↑ RF
- ↑ ACPA
RF stands for rheumatoid factor, and ACPA stands for anti-citrullinated protein antibodies.
What is the first-line treatment for Felty syndrome?
DMARD: methotrexate.
DMARD stands for disease-modifying antirheumatic drug.
What alternative treatment can be used for Felty syndrome?
Rituximab.
Rituximab is a monoclonal antibody used in various autoimmune conditions.
What should be considered for treatment of leukopenia in Felty syndrome?
Consider splenectomy to treat leukopenia and improve the disease course.
Splenectomy is the surgical removal of the spleen.
What is recommended for severe granulocytopenia in Felty syndrome?
G-CSF (granulocyte-colony stimulating factor).
G-CSF helps stimulate the production of white blood cells.
What complication does neutropenia pose in Felty syndrome?
Increases risk of recurrent bacterial infections.
This is a significant concern in managing patients.
True or False: Arthritis, splenomegaly, and neutropenia may suggest Felty syndrome.
True.
These symptoms are key indicators for diagnosis.
