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Flashcards in Teratogens Deck (20):
1

ACE Inhibitors

Renal damage

2

Alkylating agents

Absence of digits, multiple anomalies

3

Aminoglycosides

CN VIII toxicity

4

Carbamazepine

Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

5

DES (Diethylstilbestrol)

Vaginal Clear cell adenoCA, congenital Mullerian anomalies

6

Folate antagonists

Neural tube defects

7

Lithium

Ebstein anomaly (atrialized RV)

8

Methimazole

Aplasia cutis congenita

9

Phenytoin

Fetal hydantoin syndrome, microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, ID

10

Tetracyclines

Discolored teeth

11

Thalidomide

Limb defects - phocomelia, micromelia

12

Valproate

Inhibition of maternal folate absorption → neural tube defects

13

Warfarin

Bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities

14

Alcohol

Fetal Alcohol Syndrome - birth defects and ID

15

Cocaine

Abnormal fetal growth and fetal addiction, placental abruption

16

Smoking (nicotine, CO)

Leading cause of low birth weight in developed countries - preterm labor, placental problems, IUGR, ADHD

17

Iodine

Congenital goiter or cretinism

18

Maternal diabetes

Caudal regression (anal atresia), congenital heart defects, neural tube defects

19

Vitamin A excess

↑ risk for spontaneous abortions, cleft palate, cardiac abnormalities

20

X-rays

Microcephaly, intellectual disability