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Flashcards in Viral Facts Deck (47):
1

What general principle causes influenza pandemics?

Reassortment - genetic shift

2

Phenotypic mixing

Two viruses infecting one cell - Virus A takes coat B and can infect new cells - not genetically coded for

3

What are the DNA viruses?

HHAPPPPy
Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma

4

Which of the DNA viruses is single stranded?

Parvovirus

5

Which of the DNA viruses is icosahedral?

All but Pox - complex

6

Which of the DNA viruses replicates in the nucleus?

All but Pox - brings its own DNA-dep RNA Pol

7

Which DNA viruses are linear?

All but
Papilloma & Polyoma - circular, supercoiled
Hepadna - circular incomplete, has RT

8

What are the RNA viruses

I went to a retro toga party, where I drank flavored Corona and ate hippy California pickles
Retro
Toga
Flavi
Corona
Hepe
Calici
Picorna

9

Which of the RNA viruses is single stranded?

All but reovirus

10

Where does herpesvirus get its envelope from?

Nuclear membrane

11

What are the naked viruses

PAPP: Papilloma, Adeno, Parvo, Polyoma
CPRH: Calici, Picorna, Reo, Hepe

12

Hepadnavirus

HBV - has a RT

13

Sore throat, pneumonia, conjunctivits, acute hemorrhagic cystitis in campers/military recruits

Adenovirus

14

Parvovirus

B19 - aplastic crisis - fifth disease - slapped cheek rash
Fetus - hydrops fetalis and death

15

JC virus (Polyoma)

Progressive multifocal leukoencephalopathy - HIV

16

BK virus (Polyoma)

Kidney - transplant patients

17

Temporal lobe encephalitis

HSV-1

18

What 3 disease is EBV associated with?

Hodgkin lymphoma
African/Endemic Burkitt lymphoma
Nasopharyngeal CA

19

Transplant Pneumonia
AIDs Retinitis

CMV!!
Latent in mononuclear cells

20

High fevers that can cause seizures followed by diffuse macular rash

HHV-6 (Roseola)

21

Owl eye inclusions

CMV

22

Tsank test to detect multi-nucleated giant cells indicates what?

HSV + intranuclear Cowdry A inclusions

23

#1 cause of fatal diarrhea in children

Rotavirus - Reovirus

24

Polio, Echovirus, Rhinovirus, Coxsackie, HAV

Picornaviruses - aseptic meningitis

25

Norovirus

Calicivirus - viral gastroenteritis

26

HCV, yellow fever, dengue, St. Louis encephalitis, West Nile

Flavivirus

27

Rubella

Togavirus

28

Retroviruses

HIV and HTLV (T-cell leukemia)

29

Coronavirus

Common cold
SARS

30

Orthomyxovirus

-segmented ssRNA
Influenza

31

Paramyxovirus

-non segmented ssRNA
Croup - parainfluenza
RSV - bronchiolitis
Measles, Mumps

32

Aedes mosquito

Yellow fever: high fever, black vomitus, and jaundice
Monkey/human reservoir
Flavivirus

33

Rotavirus

Reovirus - dsRNA
Winter, daycare, kindergartens
Villous destruction w/ atrophy - decreased absorption of Na and loss of K

34

A humoral reponse with antibodies against ___________ of influenza virus is considered protective.

Hemagglutinin (entry)

35

All paramyxoviruses contain _________, and causes respiratory epithelial cells to fuse and form ____________________.

F-protein
Multi-nucleated cells

36

What prevents pneumonia caused by RSV in premature infants?

Palivizumab (anti-F protein)

37

What are the sequelae of Measles (rubeola)?

Subacute sclerosing panencephalitis - cerebellar/optic probs
Encephalitis
Giant cell pneumonia

38

What do you give malnourished children with measles to prevent severe exfoliative dermatitis?

Vitamin A

39

Parotitis, orchitis, and aseptic meningitis

Mumps

40

Bullet shaped virus with Negri bodies in Purkinje cells of cerebellum and in hippocampal neurons.

Rabies virus - travels to CNS via retrograde transit up axons

41

How do you treat rabies

Wound cleansing, vaccination and rabies immune globulin

42

Which of the hepatitis viruses is a DNA virus?

HBV

43

Which hepatitis virus has a high mortality in pregnant women?

HEV - waterborne epidemics - fulminant hepatitis

44

HIV gag

p24 capsid

45

HIV pol - mt results in what?

TR, aspartate protease, integrase
Drug resistance

46

HIV env mt?

Escape from host antibodies

47

Esophagitis in AIDS

Candida - patches of grey/white pseudomembranes
HSV1 - punched out ulcers
CMV - linear ucleration