Viral Facts

Question 1

What general principle causes influenza pandemics?

Answer 1

Reassortment - genetic shift

Question 2

Phenotypic mixing

Answer 2

Two viruses infecting one cell - Virus A takes coat B and can infect new cells - not genetically coded for

Question 3

What are the DNA viruses?

Answer 3

HHAPPPPy

Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma

Question 4

Which of the DNA viruses is single stranded?

Answer 4

Parvovirus

Question 5

Which of the DNA viruses is icosahedral?

Answer 5

All but Pox - complex

Question 6

Which of the DNA viruses replicates in the nucleus?

Answer 6

All but Pox - brings its own DNA-dep RNA Pol

Question 7

Which DNA viruses are linear?

Answer 7

All but
Papilloma & Polyoma - circular, supercoiled
Hepadna - circular incomplete, has RT

Question 8

What are the RNA viruses

Answer 8

I went to a retro toga party, where I drank flavored Corona and ate hippy California pickles
Retro
Toga
Flavi
Corona
Hepe
Calici
Picorna

Question 9

Which of the RNA viruses is single stranded?

Answer 9

All but reovirus

Question 10

Where does herpesvirus get its envelope from?

Answer 10

Nuclear membrane

Question 11

What are the naked viruses

Answer 11

PAPP: Papilloma, Adeno, Parvo, Polyoma
CPRH: Calici, Picorna, Reo, Hepe

Question 12

Hepadnavirus

Answer 12

HBV - has a RT

Question 13

Sore throat, pneumonia, conjunctivits, acute hemorrhagic cystitis in campers/military recruits

Answer 13

Adenovirus

Question 14

Parvovirus

Answer 14

B19 - aplastic crisis - fifth disease - slapped cheek rash

Fetus - hydrops fetalis and death

Question 15

JC virus (Polyoma)

Answer 15

Progressive multifocal leukoencephalopathy - HIV

Question 16

BK virus (Polyoma)

Answer 16

Kidney - transplant patients

Question 17

Temporal lobe encephalitis

Answer 17

HSV-1

Question 18

What 3 disease is EBV associated with?

Answer 18

Hodgkin lymphoma
African/Endemic Burkitt lymphoma
Nasopharyngeal CA

Question 19

Transplant Pneumonia

AIDs Retinitis

Answer 19

CMV!!

Latent in mononuclear cells

Question 20

High fevers that can cause seizures followed by diffuse macular rash

Answer 20

HHV-6 (Roseola)

Question 21

Owl eye inclusions

Answer 21

CMV

Question 22

Tsank test to detect multi-nucleated giant cells indicates what?

Answer 22

HSV + intranuclear Cowdry A inclusions

Question 23

1 cause of fatal diarrhea in children

Answer 23

Rotavirus - Reovirus

Question 24

Polio, Echovirus, Rhinovirus, Coxsackie, HAV

Answer 24

Picornaviruses - aseptic meningitis

Question 25

Norovirus

Answer 25

Calicivirus - viral gastroenteritis

Question 26

HCV, yellow fever, dengue, St. Louis encephalitis, West Nile

Answer 26

Flavivirus

Question 27

Rubella

Answer 27

Togavirus

Question 28

Retroviruses

Answer 28

HIV and HTLV (T-cell leukemia)

Question 29

Coronavirus

Answer 29

Common cold | SARS

Question 30

Orthomyxovirus

Answer 30

-segmented ssRNA | Influenza

Question 31

Paramyxovirus

Answer 31

-non segmented ssRNA Croup - parainfluenza RSV - bronchiolitis Measles, Mumps

Question 32

Aedes mosquito

Answer 32

Yellow fever: high fever, black vomitus, and jaundice Monkey/human reservoir Flavivirus

Question 33

Rotavirus

Answer 33

Reovirus - dsRNA Winter, daycare, kindergartens Villous destruction w/ atrophy - decreased absorption of Na and loss of K

Question 34

A humoral reponse with antibodies against ___________ of influenza virus is considered protective.

Answer 34

Hemagglutinin (entry)

Question 35

All paramyxoviruses contain _________, and causes respiratory epithelial cells to fuse and form ____________________.

Answer 35

F-protein | Multi-nucleated cells

Question 36

What prevents pneumonia caused by RSV in premature infants?

Answer 36

Palivizumab (anti-F protein)

Question 37

What are the sequelae of Measles (rubeola)?

Answer 37

Subacute sclerosing panencephalitis - cerebellar/optic probs Encephalitis Giant cell pneumonia

Question 38

What do you give malnourished children with measles to prevent severe exfoliative dermatitis?

Answer 38

Vitamin A

Question 39

Parotitis, orchitis, and aseptic meningitis

Answer 39

Mumps

Question 40

Bullet shaped virus with Negri bodies in Purkinje cells of cerebellum and in hippocampal neurons.

Answer 40

Rabies virus - travels to CNS via retrograde transit up axons

Question 41

How do you treat rabies

Answer 41

Wound cleansing, vaccination and rabies immune globulin

Question 42

Which of the hepatitis viruses is a DNA virus?

Answer 42

HBV

Question 43

Which hepatitis virus has a high mortality in pregnant women?

Answer 43

HEV - waterborne epidemics - fulminant hepatitis

Question 44

HIV gag

Answer 44

p24 capsid

Question 45

HIV pol - mt results in what?

Answer 45

TR, aspartate protease, integrase | Drug resistance

Question 46

HIV env mt?

Answer 46

Escape from host antibodies

Question 47

Esophagitis in AIDS

Answer 47

Candida - patches of grey/white pseudomembranes HSV1 - punched out ulcers CMV - linear ucleration