Flashcards in Viral Facts Deck (47):
What general principle causes influenza pandemics?
Reassortment - genetic shift
Two viruses infecting one cell - Virus A takes coat B and can infect new cells - not genetically coded for
What are the DNA viruses?
Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma
Which of the DNA viruses is single stranded?
Which of the DNA viruses is icosahedral?
All but Pox - complex
Which of the DNA viruses replicates in the nucleus?
All but Pox - brings its own DNA-dep RNA Pol
Which DNA viruses are linear?
Papilloma & Polyoma - circular, supercoiled
Hepadna - circular incomplete, has RT
What are the RNA viruses
I went to a retro toga party, where I drank flavored Corona and ate hippy California pickles
Which of the RNA viruses is single stranded?
All but reovirus
Where does herpesvirus get its envelope from?
What are the naked viruses
PAPP: Papilloma, Adeno, Parvo, Polyoma
CPRH: Calici, Picorna, Reo, Hepe
HBV - has a RT
Sore throat, pneumonia, conjunctivits, acute hemorrhagic cystitis in campers/military recruits
B19 - aplastic crisis - fifth disease - slapped cheek rash
Fetus - hydrops fetalis and death
JC virus (Polyoma)
Progressive multifocal leukoencephalopathy - HIV
BK virus (Polyoma)
Kidney - transplant patients
Temporal lobe encephalitis
What 3 disease is EBV associated with?
African/Endemic Burkitt lymphoma
Latent in mononuclear cells
High fevers that can cause seizures followed by diffuse macular rash
Owl eye inclusions
Tsank test to detect multi-nucleated giant cells indicates what?
HSV + intranuclear Cowdry A inclusions
#1 cause of fatal diarrhea in children
Rotavirus - Reovirus
Polio, Echovirus, Rhinovirus, Coxsackie, HAV
Picornaviruses - aseptic meningitis
Calicivirus - viral gastroenteritis
HCV, yellow fever, dengue, St. Louis encephalitis, West Nile
HIV and HTLV (T-cell leukemia)
-non segmented ssRNA
Croup - parainfluenza
RSV - bronchiolitis
Yellow fever: high fever, black vomitus, and jaundice
Reovirus - dsRNA
Winter, daycare, kindergartens
Villous destruction w/ atrophy - decreased absorption of Na and loss of K
A humoral reponse with antibodies against ___________ of influenza virus is considered protective.
All paramyxoviruses contain _________, and causes respiratory epithelial cells to fuse and form ____________________.
What prevents pneumonia caused by RSV in premature infants?
Palivizumab (anti-F protein)
What are the sequelae of Measles (rubeola)?
Subacute sclerosing panencephalitis - cerebellar/optic probs
Giant cell pneumonia
What do you give malnourished children with measles to prevent severe exfoliative dermatitis?
Parotitis, orchitis, and aseptic meningitis
Bullet shaped virus with Negri bodies in Purkinje cells of cerebellum and in hippocampal neurons.
Rabies virus - travels to CNS via retrograde transit up axons
How do you treat rabies
Wound cleansing, vaccination and rabies immune globulin
Which of the hepatitis viruses is a DNA virus?
Which hepatitis virus has a high mortality in pregnant women?
HEV - waterborne epidemics - fulminant hepatitis
HIV pol - mt results in what?
TR, aspartate protease, integrase
HIV env mt?
Escape from host antibodies