the actually part 2 medically important

Question 1

most imp virulence factor of s pneumoniae

Answer 1

capsular antigens

Question 2

what do capsular antigens do

Answer 2

evade phagocytosis and make specific anticapsule Ab

Question 3

is there a vaccine for s pneumoniae

Answer 3

yes

Question 4

pneumolysin causes

Answer 4

alpha hemolysis

Question 5

what is s pneumniae susceptible to

Answer 5

PCN and erythromycin

vanco for severely ill pts

Question 6

s pneumoniae beta lactamase producers?

Answer 6

no

Question 7

vaccines for s pneumoniae?

Answer 7

Prevnar 13 and Pneumovax 23

Question 8

leading cause of infectious disease in the us is from

Answer 8

meningitis

Question 9

what 2 diseases does n meningitides aka menigococcus cause

Answer 9

meningitis and meningococcemia

Question 10

what 4 diseases does n gonorrhea aka gonococcus cause

Answer 10

gonorrhea, PID, disseminated gonococcal infection (DGI), neonatal conjunctivitis

Question 11

2nd MC bact disease in US

Answer 11

gonorrhea

Question 12

tell me about neisseria

Answer 12

gram -
endotoxin in outer membrane (LOS)
grow on chocolate agar
oxidase +

Question 13

neisseria have cytochrome C which means

Answer 13

turns purple or black when exposed to phenylediamine

Question 14

neisseria meningitides host and transmission

Answer 14

humans, airbrone

Question 15

where does neisseria meningitides colonize

Answer 15

nasopharynx

Question 16

neisseria meningitides is a _____ member of the URT

Answer 16

transient

Question 17

this is higher in ppl who live in close quarters

Answer 17

neisseria meningitides

Question 18

this can seed the bloodstream and spread to the joints and meninges

Answer 18

menincogoccemia

Question 19

2 organisms cause over 80% of the cases of bacterial meningitis in infants older than 2 mo

Answer 19

streptococcus pneumoniae, and n meningitides

Question 20

MCC meningitis in ppl btwn 2 and 18

Answer 20

n meninitides

Question 21

neisseria meningitides pathogenesis

Answer 21

pyrogenic

Question 22

4 virulence factors of neisseria meningitides

Answer 22

polysaccharide capsule, endotoxin, IgA protease, FHbp (factor H binding protein)

Question 23

what does LOS cause

Answer 23

fever, shock

Question 24

what does IgA protease do?

Answer 24

helps bacteria attach to the membranes of the URT by cleaving secretory IgA

Question 25

what does FHbp do

Answer 25

binds to factor H and inhibits c3b

Question 26

pts with paroxysmal nocturnal hemoglobinuria taking eculizumab have 1000 * inc in this disease bc its a complement inhibitor

Answer 26

n meningitides

Question 27

dx of meningococcal meningitis

Answer 27

*gram - cocci seen in smears of spinal fluid

Question 28

trmt of choice for n meningitides

Answer 28

*ceftriaxone and penicillin G

Question 29

how can we prevent meningococcal disaese

Answer 29

*chemoprophylaxis and immunization

Question 30

ppx for meningococcal disaese

Answer 30

*rifampin and cipro

Question 31

humans are only natural host in

Answer 31

n meningitis and n gonorrhea

Question 32

transmission of n gonorrhea

Answer 32

genital tract MC, also anorectal and pharyngeal infections | mother--> newborn

Question 33

n gonorrhea most important virulence factor

Answer 33

*pili- mediate attachment; ones without pili cant cause disease

Question 34

2 virulence factors in cell wall of n gonorrhea

Answer 34

endotoxin LOS and outer membrane proteins

Question 35

gonococci have no _____

Answer 35

capsules

Question 36

IgA protease can hydrolyze secretory IgA which could do this in n gonorrhea

Answer 36

block attachment to mucosa

Question 37

n gonorrhea have ____ but n meninditidis dont

Answer 37

pili

Question 38

MCC septic arthritis in sexually active adults

Answer 38

disseminated infections /gonococcal bacteremia

Question 39

purulent conjunctivitis AKA

Answer 39

ophthalmia neonatorum

Question 40

trmt ophthalmia neonatorum/purulent conjunctivitis

Answer 40

ppx erythromycin eye ointment

Question 41

what may coexist with n gonorrhea

Answer 41

chlamydia trachomatis

Question 42

trmt uncomplicated n gonorrhea

Answer 42

ceftriaxone + doxycycline or azithromycin

Question 43

why is doxycycline or azithromycin added to n gonorrhea

Answer 43

1. treat any gonococcal strains resistant to ceftriaxone | 2. mixed infections withchlamydia trachomatis are common

Question 44

prevention n gonorrhea

Answer 44

condoma/barriers contact tracing erythromycin ointment

Question 45

n gonorrhea vaccine?

Answer 45

none

Question 46

n meningitidis vaccine?

Answer 46

yes

Question 47

n meningitidis make beta lactamase?

Answer 47

no

Question 48

n meningitidis ferment maltose?

Answer 48

yes

Question 49

n meningitidis have a poysaccharide capsule?

Answer 49

yes

Question 50

n meningitidis portal of entry

Answer 50

resp tract

Question 51

n gonorrhea polysaccharide capsule?

Answer 51

no

Question 52

n gonorrhea maltose fermentor?

Answer 52

no

Question 53

n gonorrhea make beta lactamase?

Answer 53

some