Flashcards in Theories of Aging Deck (14):
What are the two causes of the loss of homeostasis?
1. Breakdown in maintenance of specific molecular structures/pathways
2. overall organ system stress
Is there agreement on the definition of aging?
What is the disposable body theory?
Birth, breed, death
What is the mutation accumulation theory?
Every insult has the potential to turn on problems
What is the targeted DNA damage theory of aging?
Cumulative deletions, mutations, and translocations
What is the mitochondrial theory of aging?
Altered mito = more ROS
What is the telomere theory of aging?
Loss of telomeres
What is the error catastrophe theory of aging?
Cumulative errors in RNA and protein synthesis
What is the accumulation theory?
Accumulation of abnormal proteins that are not removed
What is a commonly missed disease in the elderly?
What are the 6 premature aging syndromes?
6. Myotonic dystrophy
What is the Ca theory of aging?
Abnormal Ca movements cause free radical damage, etc
What is the neuro-aging theory?
All cells undergo nervous system degeneration, which changes hormonal release, leading to decline in cell function