Topic 5.2 Flashcards
(44 cards)
What does heparin sulfate do?
bind antithrombin 3
What is the role of antithrombin 3?
degrades clotting factors 2, 9, 10
Which drug can increase antithrombin activity?
heparin
What is the role of thrombomodulin?
bind thrombin
What is another name of thrombin?
factor 2
What does thrombin-factor 2 do?
activates protein C
What does protein C do?
it degrades clotting factors 5 and 8
What are the 5 mechanisms of hematostasis?
- Vascular spasm
- Platelet plug
- Coagulation
- Clot retraction and repair
- Fibrinolysis
What are the 2 ways of SM contraction if damage occurs?
- endothelin secreted by endothelial cells
- stimulation of nociceptors by inflammatory chemicals
What produced VWF?
injured endothelial cells
How do platelets bind to VWF?
with the GpIb on their membrane
What 3 things do platelets release when activated?
ADP, TvA2, serotonin
What do TxA2 and ADP do?
they stimulate other platelet aggregation to site of injury
How do platelets bind together?
Gp IIb/IIIa and their membranes and fibrinogen (factor 1)
What do serotonin and TxA2 cause?
contraction by binding to SM (vascular spasm)
What happens once the platelet plug is formed?
phosphatidyl serines on the surface of the plug create a negative charge that activated factor 13
Which organ produces clotting factors?
mostly the liver
What does factor 13 do?
activated factor 12
What does factor 12 do?
Activates factor 11
What does factor 11 do?
Activated factor 9
What does factor 9 do?
forms a complex with factor 8 and together they activate factor 10
What is needed to form the factor 9/factor 8 complex?
PF3 and Ca2+
What does factor 10 do?
reacts with factor V and activates prothrombin activator
Which steps need cofactors?
- Factor 9 and 8 complex formation
- Factor 10 and 5 interaction
