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Uworld Gaby > UW 16 > Flashcards

UW 16 Flashcards

(49 cards)

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1
Q

Glazman thrombastenia

A

Platelet aggregation deficit

Mucocutaneous bleeding

Normal platelet count. No clumping on peripheral blood smear

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2
Q

Cholangio carcinoma markers vs. Hepatocellular

A

Cholangio carcinoma: CA 19-9 and CAE

Hepatocellular: AFP

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3
Q

Systemic sclerosis antibodies

A

Limited cutanueos: Anticentromere

Difuse: anti polymerase 3 and ScL-70 (topoisomerase 1)

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4
Q

Delivery management of preeclampsia

A

Delivery at 37 weeks.

Severe features after 34 weeks: Delivery
Induction of labor preferred over C-section

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5
Q

Preeclampsia with severe features

A

BP: >160/110

Thrombocytopenia
> Creatinine
> LFTs
Headache or neurological symptoms
Pulmonary edema
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6
Q

Fetal fibronectin test

A

Done in patients <33+6 weeks gestation to predict preterm labor.

Positive test is good predictor of preterm labor within a week and an indication for IM corticosteroid injection

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7
Q

Pathology of Lewi body dementia

A

Deposition of alpha-synuclein bodies in the substantia nigra and brain stem

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8
Q

Examples of primitive relfexes and what do they suggest in an adult

A

Sucking, roting, glabelar

Frontotemporal dementia

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9
Q

Startle myoclonus definition and asssociation

A

Myoclonus/jerk with loud auditory stimulus

Prion disease (Creutzfeld-Jacob)

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10
Q

Dementia with Lewi bodies

A

Visual Hallucinations
Fluctuating cognition (may be describes as good moments and bad moments)
Parkinsonism
REM sleep behavior disorder

Other symptoms that might suggest:
Frequent falling
Sensitivity to antipsychotics

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11
Q

Dementia with Lewi bodies

A

Visual Hallucinations
Fluctuating cognition (may be describes as good moments and bad moments)
Parkinsonism
REM sleep behavior disorder

Other symptoms that might suggest:
Frequent falling
Sentivity to antipsychotics
syncope/near syncope
autonomic dysfuntion
SPECT or PET showing low dopapine transport in basal ganglia
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12
Q

Lewi body dementia management

A

Parkinsonism: levo/carvidopa

Cholinesterase inhibitor: rivastigmine for cognitive impairment

Anti psychotics for functional impeding hallucinations

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13
Q

FACT:

If GBS status is not mentioned on the question. Consider it unknown. What do you do?

A

Screening 36-38

IV penicillin if
1. GBS UTI during pregnancy regardless of treatment
2. Colonation of GBS (GU and/or rectum)
3. Hx of early onset neonetal sepsis
4. Unknown status and...
..... <37 weeks
.... Intrapartum fever
.... Rupture of membranes >18 hrs
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14
Q

Vit C deficiency pathological effect

A

Impaired wound healing due to poor collagen formation

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15
Q

Niacin deficiency

A

Pellagra

Dermatitis
Diarrhea
Dementia/Delusions

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16
Q

Livido reticularis associations

A

Vasculitis:
Polyarteritis nodosa, SLE

Vasocclusive
Fat embolism, Antiphospholipid sd, cryoglobulinemia

May be normal in some people specially in cold climates

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17
Q

Antiphosppholipid sd coagulation studies

A

Normal PT
Prolonged PTT

Mixing of patient blood with donor plasma will not correct PTT (unlike factor deficiency)

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18
Q

Elevated B2-microglobulin

A

Multiple Myeloma

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19
Q

Common dermal manifestation of Antiphospholipid sd

A

Livido reticularis

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20
Q

Specific antiphospholipid antibodies

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A

Anticardiolipin
Antiphosphatidilserine
Anti beta2 glycoprotein

21
Q

Retained product of conception

Risk and complication

Study These Flashcards
A

No placental expulsion after 30 min

Can cause post partum hemorrhage and infection

Increased risk if 24-27 weeks, still birth, placenta acreta, previous hx

22
Q

Chemo induced cardiac damege

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A

Doxorubicin (and its family that end in rubicin): fibrosis. Not reversible

Trastuzumab: stunnin/dormant/hybernation cardiomyocytes. Asymptomatic ventricular systolic dysfunction

23
Q

Hystologic finding in hypertrophic cardiomyopathy

Study These Flashcards
A

Cardiomyocyte hypertrophy and disarray

24
Q

Painless penile ulcer that has been present for a few months

Study These Flashcards
A

Cancer (Usually SCC)

Syphilis self resolve in 2-6 weeks if left untreated

25
Penile Cancer
Risk factors: VPH, smocking Presentation: chronic painless ulcer + regional lymphadenopathies Diagnosis: biopsy Management: Excision
26
Massive transfusion protocol
Packed RBC, FPP and platalets 1:1:1 ratio to avoid coagulopathy from delution of platelets and coagulation factors Indicated in patients with hypovolemic shock that failed initial resuscitation efforts
27
FACT Always stabilize the patient first.. then do imaging studies
Unstable patients cant wait for blood matching. Give O type blood
28
Cortical bone loss
Primary hyperparathyroidsm
29
McCune albright sd
Constant activated G protein Elevated TSH: thyrotoxicosis Elevated LH/FSH: precosious buberty (breast and pubic hair development) Elevated ACTH: cushing sd Caffe aulit spots, fibrous dysplasia of the bone
30
Fibrous dysplasia of the bone association
McCune albright sd
31
Defective mineralization of osteoid
Osteomalasia/osteoporosis
32
Bipolar I vs II diagnosis
I: One manic episode (need for hospitalization) II: Hx of hypomanic episodes (lasting over 4 days) At least one MDD episode
33
Clasic triad of Hemochromatosis
Cirrhosis Diabetes Skin pigmentation Found only late in the disease
34
Hemochromatosis ``` Skin Gastro M/E Cardio Endocrine Infection ```
Skin: hyperpigmentation Gastro: elevated LFTs and hepatomegaly (early), cirrhosis (late), risk for hepatocellular carcinoma M/E: arthritis, chondrocalcinosis, arthralgias Cardio: dilated or restrictive cardiomyopathy, conduction abnormalities Endocrine: DM, hypogonadism (low libido, impotence in men), hypothyroidsm Infection: Yersnia, vibrio,
35
Asymptomatic patient with LFTs
Hemochromatosis in dxx
36
Hemochromatosis ``` Skin Gastro M/E Cardio Endocrine Infection ``` Diagnosis
Skin: hyperpigmentation Gastro: elevated LFTs and hepatomegaly (early), cirrhosis (late), risk for hepatocellular carcinoma M/E: arthritis, chondrocalcinosis, arthralgias Cardio: dilated or restrictive cardiomyopathy, conduction abnormalities Endocrine: DM, hypogonadism (low libido, impotence in men), hypothyroidsm Infection: Yersnia, vibrio, DIagnosis: genetic HFE mutation
37
Initial management of acute pancreatitis
Aggressive IV fluids Pain management Monitoring complications (infection, renal failure, ARDS) Empiric ATB not indicated unless CT evidence of necrosis
38
Dxx of erectyle dysfunction
Absence of nocturnal erections: Neurologic: diabetic neuropathy, MS, spinal injury Cardiovascular: smocking, claudication, DM, hypertension Nocturnal erections: Psycologic: specific to a person, situation, sudden onsent Hypogonadism: Decreased libido, testicular atrophy, gynecosmastia, gradual onset, low testotorone Endocrine: hypothyroidsm, prolatinoma Hemochromatosis Medications: antidepresants, SSRI, antiandrogenic medication
39
Clues for masotiditis
Inflammation of mastoid lowers ear
40
Suction splash on physical examination How do you produce it? What does it mean
Stethoscope on epigastric region, rock the patient back and forth at the hip Associated with gastric outlet obstruction
41
Calcium-phosphorous product
Ca x PO4 = >55 risk for tissue calcification Can cause basal ganglia calcification and symptoms of parkinsonism Low Ca and high PO4 is seen in secondary hyperparathyroidsm
42
Good or bad pronostic factor of schizofrenia
``` GOOD: Female Late onset Mostly positive symptoms Identifiable precipitant /acute onset ``` ``` BAD: Early onset (childhood, adolescence) Family hx Long duration of symptoms without treatment Presence of negative symptoms Gradual onset ```
43
Good or bad prognostic factor of schizophrenia
``` GOOD: Female Late onset Mostly positive symptoms Identifiable precipitant /acute onset ``` ``` BAD: Early onset (childhood, adolescence) Family hx Long duration of symptoms without treatment Presence of negative symptoms Gradual onset ```
44
Auer rods
AML
45
Brief psychotic disorder
>1d and <1month Sudden onset Return to baseline
46
Schizophreneiform disorder
>1 month <6 months Same symptos as schizofrenia. Functional decline not requiered
47
Schizophrenia
>6 month of symptoms With funtional decline >1 month of active symptoms
48
Schizoafective
2 years Mood episode (depresion or bipolar) + schizophrenia > 2weeks episode of schizophrenia without mood symptoms
49
Delusional disorder
>1 delusion >1 months without any other symptom

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