UWorld Day Nine

Question 1

difference in leukocyte (neutrophil) alkphos between CML and leukemoid reaction?

Answer 1

CML - decreased alk phos

Leukemoid - normal or increased

Question 2

~blast =

~cyte =

Answer 2

blast = malignancy
cyte = leukemoid rxn or pregnancy

Question 3

hematomas:

• lucid interval, MMA
• gradual sx onset, bridging cortical veins
• worst HA of life + fever and nuchal rigidity

Answer 3

• epidural (lens shaped)
• subdural hematoma (crescent shaped)
• SAH (berry aneurysm in ACA or PCA)

Question 4

koilocytes

Answer 4

HPV

Question 5

multinucleated giant cell bodies and keratinocytes

Answer 5

herpes zoster

Question 6

keratinization /keratin pearls indicates what what type of cell?

Answer 6

squamous cell differentiation

Question 7

what compartment:

• deep peroneal nerve and anterior tibial aa/vv
• superficial peroneal nerve
• tibial nerve, posterior tibial aa/vv, peronal aa/vv
• n/a - just muscle

Answer 7

• anterior compartment
• lateral compartment
• deep posterior compartment
• superficial posterior compartment

Question 8

funciton of Bcl-2 gene

Answer 8

inhibits apoptosis of tumor cells by inhibiting cell death cascade

Question 9

DNA mismatch repair mutations lead to…

Answer 9

HNPCC (Lynch syndrome)

Question 10

antibody in polymyositis

Answer 10

anti-jo-1

anti-histydyl-tRNA synthetase

Question 11

low serum levels of C1 esterase

Answer 11

hereditary angioedema = d/t of bradykinin

ACEinhibitors are contraindicated

Question 12

G+ that synthesizes dextrans from sucrose

Answer 12

viridans strep

Question 13

what type of G+ bug uses dextrans to facilitate adherence to fibrin, which is deposited at sites of endothelial trauma

Answer 13

viridans strep

Question 14

the following are indicative of ____:

1. hepatic dysfunction with microvesicular steatosis without inflammation
2. encephalopathy

Answer 14

reye syndrome in a child

Question 15

mutationin PPRP leads to

Answer 15

gout

Question 16

what finiding will ALWAYS be present in TTP

Answer 16

hemolytic anemia

Question 17

light blue basophilic peripheral granules in neutrophils, aka Dohle Bodies.

increased alk phos

Answer 17

leukemoid reaction

Question 18

early amture neutrophil precursors, (myelocytes), granule sin neutrophils (dohle bodies), inrased bands on Peripheral blood smear.

Answer 18

leukemoid reaction

Question 19

virus that causes acute fever, cough, congestion, phayngitis, conjuctivitis. Outbreaks in crowded quarters

Answer 19

adenovirus

Question 20

virus that destroys erythroid precursors, thus diminisheing number of reticulocytes available to replace deformed an/or removed erythrocytes. in sickle cell

Answer 20

parvo B19 - causing aplastic crisis

Question 21

cataracts, frontal balding, gonadal atrophy, sustained muscle fiber (type 1) contraction.

Answer 21

myotonic dystrophy

Question 22

• Loss of BILATERAL UE pain and temp
• UE weakness and hyporeflexia (LMN signs)
• LE weakness and hyperreflexia (UMN signs)
• kyphoscoliosis.

Answer 22

syringomyelia

Question 23

UMN, LMN disease

Answer 23

ALS

Question 24

posterior fossa tumor in children that causes sx realted to obstructive hydrocephalus

Answer 24

medulloblastoma

Question 25

the 2 substances that are the predominant promotors of angiogenesis

Answer 25

VEGF | FGF-2

Question 26

pancytopenia, - biopsy - hypocellular bone marrow composed of fat and stromal cells --> "dry tap" - pancytopenia- anemia, thrombocytopenia, leukopenia no SM

Answer 26

aplastic anemia

Question 27

severe B12 deficiency anemia, folic acid deficiency anemia, acute leukemia, Myelodysplastic syndrome - all present with?

Answer 27

pancytopenia wihtout SM

Question 28

what are these LoF mutaitons? 1. inactivated in Familial Adenomatis Polyposis and many sporadic colon cancers. 2. normally responsible for DNA repair - breast and ovarian cancer risk 3. normally inhibits G1 to S 4. prodcues p53, Li-Fraumeni ssyndrome

Answer 28

1. APC 2. BRCA1 3. RB 4. TP53

Question 29

CML an d ALL proto oncogene

Answer 29

ABL

Question 30

BRAF protooncogene

Answer 30

melanoma

Question 31

HER1 protooncogene

Answer 31

Squamous cell lung cancer

Question 32

HER2 protooncogene | also assocaited with Erb-B2

Answer 32

breast and ovarian cancer

Question 33

SIS protooncogene

Answer 33

astrocytoma and osteosarcoma

Question 34

TGFA protooncogene

Answer 34

astrocytoma and HCCa

Question 35

VHL tumor suppressor gene

Answer 35

VHL-syndrome and Rencal cell cancer

Question 36

LEMS or MG? hyporeflexia or areflexia, autonomic sx, incremental response to repetative stimulatino

Answer 36

LEMS **Small cell lung cancer

Question 37

- complication of Ulcerative colitis that dissallows colonoscopy or barium contrast studies - sx are abd pain/distension, bloody diarrhea, fever, signs of shock

Answer 37

toxic megacolon

Question 38

RA results in what spinal abnormlaities?

Answer 38

cervical subluxation that can affect the atlantoaxial joint.