Flashcards in UWorld Day Nine Deck (38):
difference in leukocyte (neutrophil) alkphos between CML and leukemoid reaction?
CML - decreased alk phos
Leukemoid - normal or increased
blast = malignancy
cyte = leukemoid rxn or pregnancy
-lucid interval, MMA
-gradual sx onset, bridging cortical veins
-worst HA of life + fever and nuchal rigidity
-epidural (lens shaped)
-subdural hematoma (crescent shaped)
-SAH (berry aneurysm in ACA or PCA)
multinucleated giant cell bodies and keratinocytes
keratinization /keratin pearls indicates what what type of cell?
squamous cell differentiation
-deep peroneal nerve and anterior tibial aa/vv
-superficial peroneal nerve
-tibial nerve, posterior tibial aa/vv, peronal aa/vv
-n/a - just muscle
-deep posterior compartment
-superficial posterior compartment
funciton of Bcl-2 gene
inhibits apoptosis of tumor cells by inhibiting cell death cascade
DNA mismatch repair mutations lead to...
HNPCC (Lynch syndrome)
antibody in polymyositis
low serum levels of C1 esterase
hereditary angioedema = d/t of bradykinin
ACEinhibitors are contraindicated
G+ that synthesizes dextrans from sucrose
what type of G+ bug uses dextrans to facilitate adherence to fibrin, which is deposited at sites of endothelial trauma
the following are indicative of ____:
1. hepatic dysfunction with microvesicular steatosis without inflammation
reye syndrome in a child
mutationin PPRP leads to
what finiding will ALWAYS be present in TTP
light blue basophilic peripheral granules in neutrophils, aka Dohle Bodies.
increased alk phos
early amture neutrophil precursors, (myelocytes), granule sin neutrophils (dohle bodies), inrased bands on Peripheral blood smear.
virus that causes acute fever, cough, congestion, phayngitis, conjuctivitis. Outbreaks in crowded quarters
virus that destroys erythroid precursors, thus diminisheing number of reticulocytes available to replace deformed an/or removed erythrocytes. in sickle cell
parvo B19 - causing aplastic crisis
cataracts, frontal balding, gonadal atrophy, sustained muscle fiber (type 1) contraction.
-Loss of BILATERAL UE pain and temp
-UE weakness and hyporeflexia (LMN signs)
-LE weakness and hyperreflexia (UMN signs)
UMN, LMN disease
posterior fossa tumor in children that causes sx realted to obstructive hydrocephalus
the 2 substances that are the predominant promotors of angiogenesis
-biopsy - hypocellular bone marrow composed of fat and stromal cells --> "dry tap"
-pancytopenia- anemia, thrombocytopenia, leukopenia
severe B12 deficiency anemia, folic acid deficiency anemia, acute leukemia, Myelodysplastic syndrome - all present with?
pancytopenia wihtout SM
what are these LoF mutaitons?
1. inactivated in Familial Adenomatis Polyposis and many sporadic colon cancers.
2. normally responsible for DNA repair - breast and ovarian cancer risk
3. normally inhibits G1 to S
4. prodcues p53, Li-Fraumeni ssyndrome
CML an d ALL proto oncogene
Squamous cell lung cancer
(also assocaited with Erb-B2)
breast and ovarian cancer
astrocytoma and osteosarcoma
astrocytoma and HCCa
VHL tumor suppressor gene
VHL-syndrome and Rencal cell cancer
LEMS or MG?
hyporeflexia or areflexia, autonomic sx, incremental response to repetative stimulatino
**Small cell lung cancer
-complication of Ulcerative colitis that dissallows colonoscopy or barium contrast studies
-sx are abd pain/distension, bloody diarrhea, fever, signs of shock