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Flashcards in UWorld Day Nine Deck (38):
1

difference in leukocyte (neutrophil) alkphos between CML and leukemoid reaction?

CML - decreased alk phos
Leukemoid - normal or increased

2

~blast =
~cyte =

blast = malignancy
cyte = leukemoid rxn or pregnancy

3

hematomas:
-lucid interval, MMA
-gradual sx onset, bridging cortical veins
-worst HA of life + fever and nuchal rigidity


-epidural (lens shaped)
-subdural hematoma (crescent shaped)
-SAH (berry aneurysm in ACA or PCA)

4

koilocytes

HPV

5

multinucleated giant cell bodies and keratinocytes

herpes zoster

6

keratinization /keratin pearls indicates what what type of cell?

squamous cell differentiation

7

what compartment:
-deep peroneal nerve and anterior tibial aa/vv
-superficial peroneal nerve
-tibial nerve, posterior tibial aa/vv, peronal aa/vv
-n/a - just muscle


-anterior compartment
-lateral compartment
-deep posterior compartment
-superficial posterior compartment

8

funciton of Bcl-2 gene

inhibits apoptosis of tumor cells by inhibiting cell death cascade

9

DNA mismatch repair mutations lead to...

HNPCC (Lynch syndrome)

10

antibody in polymyositis

anti-jo-1
anti-histydyl-tRNA synthetase

11

low serum levels of C1 esterase

hereditary angioedema = d/t of bradykinin

ACEinhibitors are contraindicated

12

G+ that synthesizes dextrans from sucrose

viridans strep

13

what type of G+ bug uses dextrans to facilitate adherence to fibrin, which is deposited at sites of endothelial trauma

viridans strep

14

the following are indicative of ____:
1. hepatic dysfunction with microvesicular steatosis without inflammation
2. encephalopathy

reye syndrome in a child

15

mutationin PPRP leads to

gout

16

what finiding will ALWAYS be present in TTP

hemolytic anemia

17

light blue basophilic peripheral granules in neutrophils, aka Dohle Bodies.

increased alk phos

leukemoid reaction

18

early amture neutrophil precursors, (myelocytes), granule sin neutrophils (dohle bodies), inrased bands on Peripheral blood smear.

leukemoid reaction

19

virus that causes acute fever, cough, congestion, phayngitis, conjuctivitis. Outbreaks in crowded quarters

adenovirus

20

virus that destroys erythroid precursors, thus diminisheing number of reticulocytes available to replace deformed an/or removed erythrocytes. in sickle cell

parvo B19 - causing aplastic crisis

21

cataracts, frontal balding, gonadal atrophy, sustained muscle fiber (type 1) contraction.

myotonic dystrophy

22

-Loss of BILATERAL UE pain and temp
-UE weakness and hyporeflexia (LMN signs)
-LE weakness and hyperreflexia (UMN signs)
-kyphoscoliosis.

syringomyelia

23

UMN, LMN disease

ALS

24

posterior fossa tumor in children that causes sx realted to obstructive hydrocephalus

medulloblastoma

25

the 2 substances that are the predominant promotors of angiogenesis

VEGF
FGF-2

26

pancytopenia,
-biopsy - hypocellular bone marrow composed of fat and stromal cells --> "dry tap"
-pancytopenia- anemia, thrombocytopenia, leukopenia

no SM

aplastic anemia

27

severe B12 deficiency anemia, folic acid deficiency anemia, acute leukemia, Myelodysplastic syndrome - all present with?

pancytopenia wihtout SM

28

what are these LoF mutaitons?
1. inactivated in Familial Adenomatis Polyposis and many sporadic colon cancers.
2. normally responsible for DNA repair - breast and ovarian cancer risk
3. normally inhibits G1 to S
4. prodcues p53, Li-Fraumeni ssyndrome

1. APC
2. BRCA1
3. RB
4. TP53

29

CML an d ALL proto oncogene

ABL

30

BRAF protooncogene

melanoma

31

HER1 protooncogene

Squamous cell lung cancer

32

HER2 protooncogene
(also assocaited with Erb-B2)

breast and ovarian cancer

33

SIS protooncogene

astrocytoma and osteosarcoma

34

TGFA protooncogene

astrocytoma and HCCa

35

VHL tumor suppressor gene

VHL-syndrome and Rencal cell cancer

36

LEMS or MG?

hyporeflexia or areflexia, autonomic sx, incremental response to repetative stimulatino

LEMS

**Small cell lung cancer

37

-complication of Ulcerative colitis that dissallows colonoscopy or barium contrast studies
-sx are abd pain/distension, bloody diarrhea, fever, signs of shock

toxic megacolon

38

RA results in what spinal abnormlaities?

cervical subluxation that can affect the atlantoaxial joint.