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Flashcards in Genetics Deck (12):
1

L-myc

Small Cell/Oat Cell Lung Cancer
amplification, nuclear regulatory protein

2

N-myc

neurblastoma
amplification, nuclear regulatory protein

3

t(8;14)

C-myc; Burkitt Lymphoma
translocation
translocation, nuclear regulatory protein

4

t(9;22)

Chronic Myelogenous Leukemia
abl-bcr
translocation

5

cdk4 assciated with ___ cancers

malignant melanoma and glioblastoma multiforme

6

function of CDK4 kinase

binds to cyclin D1 to phorphorylate Rb gene product. (hyperphosphorylation = inhibits function

7

erb-2

breast, ovary, stomach
Gene product - EGFR
Amplification

8

ret

medullary thyroid carcinoma (think MEN2a and 2b
point mutation

9

Ki-ras

lung, pancreas, colon
GTP binding protein

10

erb-B1 and erb-B3

erb-B1 - SCC of lung, EGFR, overexpression
erb-B3 - breast, EGFR, overespression

11

sis

astrocytoma

platelet derived growth factor,
overexpression

12

CDH1

encodes E-cadherin,

high risk of gastric adenocarcinoma and infiltrating lobular carcinoma