Flashcards in UWorld - Day Two Pharm Drugs Deck (29)
TMP-SMX, dapsone, and antimalarials can cause hemolytic anemia in patients with what enzyme deficiency?
Is calcidiol or cancitriol the active form of vitamin D?
teratogenicity of aminoglycosides in utero
ototoxicity and vestibulotoxicity (affect cn8)
teratogenicity of TMP-SMX in utero
neural tube defects
teratogenicity of tetracyclines in utero
teeth staining of offspring
teratogenicity of chloramphenicol in utero
Avoid in what group:
alpha blockers (orthostatic hypotension)
muscle relaxants (sedation)
Neuromuscular excitation: hyperreflexia, clonus, myoclonus, rigidity, tremor
Autonomic Stimulation: hyperthermia, tachycardia, diaphoresis, vomiting/diarrhea
AMS - agitation and confusion
What caused this?
The etiology is a derivative of what amino acid?
This is serotonin syndrome, caused by OD on SSRIs and/or MAOs.
serotonin is a derivative of tryptophan
cyroheptadine is the antidote for what toxicity?
it's an anti-histamine
Antidote for benzodiazepine overdose
Antidote for narcotic overdose
Carbamazepine, chloramphenicol, sulphonamides, parvo, EBV - all can cause what?
red man syndrome - AE of what drug?
N/V/cramy abdominal pain, paresthesias and dizziness - AE of wha drug?
vestibular and cochlear otoxicity, nephrotoxicity, and neuromuscular paralysis - SE of what drug?
B1 blocker effects on heart and kidney. And AE
heart - dec HR, decr contractility, decr O2 consumption (used in acute MI)
kidney - decr renin release
AE - worsen HF, bradycardia/Heart block
B2 blocker effects on muscle vaculature. And AE.
vasospasm. AE - exacerbation of peripheral artery disease
B2 blcoer effects on lungs and AE.
AE worsen obstructive lung disease
B2 blocker effectson liver and AE.
decr glycogenolysis and gluconeogenesis. AE - hypoglycemia in diabetics
B2 blocker effects on most tissues. and AE
decreases potsassium entry into cells. AE - hyperkalemia
what class inhibits viral genome replication by inhibiting the 2'-5' phosphodiester bond formation.
-dine class of anit-HIV
First order kinetic drugs (dependent on drug ) reach a 95% steady state when continuously infused by how many hours?
4-5 half lives.
Drug class used to tx a pt with low back pain, fatigue, hyperCa, anemia, kidney disease.
This is MM - use proteasome inhibitors to induce apoptosis.
Must do TB skin test before administering this class of drugs. What is the class (and drugs) and used for what diseases?
TNF-alpha inhibitors. TB test bc TNF is important in granuloma formation.
etanercept - RA, psoriasis, ankylosing spndylitis
Infliximab, adalimumab - IBD and same as above
tamixifen v. trastuzumab
tamixifen is for premenopausal breast cancer pts with this serm
Trastuzumab is a Human Epidermal Receptor-2 (TK-receptor) used to x breast cancer.
Denosumab - what is it.
receptor activator of NFK-beta ligand (RANKL) that activates osteoclasts.
bethanachol v. pilocarpine/carbachol as cholinergic-agonists
bethanachol for post op ileus
other two for galucoma to lower intraocular pressure by incrasing flow of aqueous humor
both = miosis and cholinergic potential toxicities (DUMBBELLS)
What drugs should not be given to pts with prinzmental angina?
Migrane drugs - i.e. dihydroerogtamin alkaloids/tripans (cause vasoconstriction), cocaine/amphetamine, cigarette smoking