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Flashcards in UWorld - Day Two Pharm Drugs Deck (29):
1

TMP-SMX, dapsone, and antimalarials can cause hemolytic anemia in patients with what enzyme deficiency?

G6PD

2

Is calcidiol or cancitriol the active form of vitamin D?

calcitriol

3

teratogenicity of aminoglycosides in utero

ototoxicity and vestibulotoxicity (affect cn8)

4

teratogenicity of TMP-SMX in utero

neural tube defects

5

teratogenicity of tetracyclines in utero

teeth staining of offspring

6

teratogenicity of chloramphenicol in utero

gray baby

7

Avoid in what group:
antihistamines (diphenhydramine)
alpha blockers (orthostatic hypotension)
TCAs (sedation)
sulfonylureas (hypoglycemia)
muscle relaxants (sedation)

elderly

8

Neuromuscular excitation: hyperreflexia, clonus, myoclonus, rigidity, tremor
Autonomic Stimulation: hyperthermia, tachycardia, diaphoresis, vomiting/diarrhea
AMS - agitation and confusion

What caused this?
The etiology is a derivative of what amino acid?

This is serotonin syndrome, caused by OD on SSRIs and/or MAOs.

serotonin is a derivative of tryptophan

9

cyroheptadine is the antidote for what toxicity?

serotonin sydnrome

it's an anti-histamine

10

Antidote for benzodiazepine overdose

flumazenil

11

Antidote for narcotic overdose

naloxone

12

Carbamazepine, chloramphenicol, sulphonamides, parvo, EBV - all can cause what?

aplastic anemia

13

red man syndrome - AE of what drug?

vancomycin

14

N/V/cramy abdominal pain, paresthesias and dizziness - AE of wha drug?

metronidazole

15

vestibular and cochlear otoxicity, nephrotoxicity, and neuromuscular paralysis - SE of what drug?

gentamycin

16

B1 blocker effects on heart and kidney. And AE

heart - dec HR, decr contractility, decr O2 consumption (used in acute MI)
kidney - decr renin release

AE - worsen HF, bradycardia/Heart block

17

B2 blocker effects on muscle vaculature. And AE.

vasospasm. AE - exacerbation of peripheral artery disease

18

B2 blcoer effects on lungs and AE.

brocnhoconstriction
AE worsen obstructive lung disease

19

B2 blocker effectson liver and AE.

decr glycogenolysis and gluconeogenesis. AE - hypoglycemia in diabetics

20

B2 blocker effects on most tissues. and AE

decreases potsassium entry into cells. AE - hyperkalemia

21

what class inhibits viral genome replication by inhibiting the 2'-5' phosphodiester bond formation.

-dine class of anit-HIV

22

First order kinetic drugs (dependent on drug []) reach a 95% steady state when continuously infused by how many hours?

4-5 half lives.

23

Drug class used to tx a pt with low back pain, fatigue, hyperCa, anemia, kidney disease.

This is MM - use proteasome inhibitors to induce apoptosis.

24

Must do TB skin test before administering this class of drugs. What is the class (and drugs) and used for what diseases?

TNF-alpha inhibitors. TB test bc TNF is important in granuloma formation.
etanercept - RA, psoriasis, ankylosing spndylitis
Infliximab, adalimumab - IBD and same as above

25

tamixifen v. trastuzumab

tamixifen is for premenopausal breast cancer pts with this serm
Trastuzumab is a Human Epidermal Receptor-2 (TK-receptor) used to x breast cancer.

26

Denosumab - what is it.

receptor activator of NFK-beta ligand (RANKL) that activates osteoclasts.

27

bethanachol v. pilocarpine/carbachol as cholinergic-agonists

bethanachol for post op ileus
other two for galucoma to lower intraocular pressure by incrasing flow of aqueous humor

both = miosis and cholinergic potential toxicities (DUMBBELLS)

28

What drugs should not be given to pts with prinzmental angina?

Migrane drugs - i.e. dihydroerogtamin alkaloids/tripans (cause vasoconstriction), cocaine/amphetamine, cigarette smoking

29

Fenoldopam is given IV in HTN emergency - why? What are it's effects?

Bc it is a D1-receptor agonist, so it activates AC which increases cAMP and causes ateriolar vasodilation, especially in renal arteries.