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Step 1 > UWORLD random 3/20b > Flashcards

UWORLD random 3/20b Flashcards

1
Q

actin & myosin bound to structural proteins where?

A

actin = z-line

myosin = M line

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2
Q

pancreas embryology

dorsal vs ventral buds

A

dorsal = tail, body, most of head, small accessory duct

ventral = uncinate process, portion of head, prox portion of main duct

fuse in 8th week

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3
Q

immune response to TB mediated by…

A

CD4+ T cells

macrophages –> langhans giant cells

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4
Q

thrombus in a fib formed where?

A

left atrial appendage

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5
Q

efficacy

A

intrinsic ability of drug to elicit effect

max ceiling of activity irrespective to dose

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6
Q

potency

A

dose of drug required to produce given effect

limited by affinity – higher affinity = higher potency

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7
Q

parasites that cause disease in RBCs

A

plasmodium

babesiosis

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8
Q

babesiosis sx

A 
flu
myalgias
headache
fever
fatigue

anemia
thrombocytopenia
+ LFTs

splenomegaly

NE USA

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9
Q

dx mucormycosis

A

histology of affected tissue

broad nonseptate hyphae with right angle branching

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10
Q

time period for dx major depressive disorder

A

> 2 weeks

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11
Q

dermatomyositis

A

autoimmune
inflammatory myopathy

pottron papules = joints, bony prominences
heliotrop rash = eyelids
myopathy = prox muscle weakness

anti-jo-1
ANA

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12
Q

intraabdominal infxn most common pathogen

A

b fragilis

e coli

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13
Q

short - intermed term benzos

A

tria
oxa
mida

alpra
lora
tema

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14
Q

long acting benzos

A

dia
chlordia
flura

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15
Q

CF mutation

A

impaired post translational processing of CFTR

delete Phe at 508

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16
Q

neurophysin

A

carrier proteins for oxytocin and vasopressin to release from post pit

mut = AD hereditary hypothalamic diabetes insipidus

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17
Q

anthracyclines ADR

A

-rubicin

free radicals –>
severe cardiotoxicity = dilated cardiomyopathy

18
Q

monitor hydatidiform moles via

A

b-hCG

19
Q

shoulder trauma nerve injury

A

axillary nerve

sensory loss over lateral shoulder and weakness on shoulder abduction

20
Q

Kawasaki disease complication

A

coronary artery disease

21
Q

Kawasaki disease sx

A 
fever >5 days
bilateral non-exudative conjunctival injection
cervical lymphadenopathy
mucositosis
extremity changes
rash

asians

22
Q

foscarnet

A

pyrophosphate analog that does not require intracellular activation

directly inhibits DNA pol and reverse transcriptase

23
Q

intranuclear and intracytoplasmic inclusions

A

CMV

24
Q

inhaled anesthetic hepatotoxicity

A

halothane

fulminant hepatitis
shrunken liver

fever, anorexia, nausea, myalgias, arthralgias, rash
jaundice
\+ ALT,AST
\+ PTT
leukocytosis, eosinophilia
25
Q

methemoglobinemia - normal arterial blood values?

A

partial pressure of oxygen in blood

methemoglobin cannot bind oxygen

26
Q

menorrhagia and epistaxis as a kid

A

vWF deficiency

27
Q

vWF binds…

A

glycoproteins and collagen

carries factor VIII

28
Q

latanoprost

A

topical PG treats open angle glaucoma

increase outflow of aqueous humor

29
Q

NF-kB

A

proinflam transcription factor
increase cytokine production
inhibited in Crohns with NOD2 mutations

30
Q

mitral valve stenosis murmur

A

opening snap
diastolic rumbling
apex

31
Q

osmotic laxative mimics…

A

lactase deficiency

polyethylene glycol
magnesium hydroxide

32
Q

benzos DDI

A

first gen H1 antagonists

diphenhydramine
chlorpheniramine

33
Q

“water under the bridge”

A

uterine artery grosses over anterior surface of ureter

34
Q

complications of varicose veins

A 
painful thromboses
stasis dermatitis
skin ulcerations
poor wound healing
superficial infections
35
Q

Neimman Pick

A

AR
sphingomyelinase deficiency

hepatosplenomegaly
CNS sx
cherry red macular spot

Ashkenazi Jews

36
Q

a/p stenosis murmur

A

crescendo decrescendo systolic murmuer

37
Q

bladder cancer prognosis markers

A

** degree of invasion

38
Q

motor innervation of tongue

A

hypoglossal nerve

palatoglossus = vagus

39
Q

general sensory innervation of tongue

A

ant 2/3 = CNV3

post 1/3 = glossopharyngeal

post tongue root = vagus

40
Q

taste innervation of tongue

A

ant 2/3 = chorda tympani of facial

post 1/3 = glossopharyngeal

post tongue root/larynx/upper esophagus = vagus

41
Q

plasma cell neoplasm

A

multiple myeloma = RBC rouleaux, Bence-Jones proteins in urine

anemia, lytic bone lesions, renal insufficiency

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