Viral Skin Infections

Question 1

What are the 4 functions of the skin?

Answer 1

1. Protection
2. Thermoregulation
3. Immunologic
4. Synthetic Function

Question 2

What are the cells of the epidermis?

Answer 2

• Keratinocyte
• Melanocyte
• Langerhans cells

Question 3

Keratinocytes produce keratin which forms the

Answer 3

outer most skin layer covered by thin lipids to give protective capacity from water and heat loss, penetration of microbial agents and other trauma by physical mechanisms

Question 4

What are langerhans’ cells?

Answer 4

Cells with dendrite processes specialized in antigen processing and presentation (building immunity to infection)

Question 5

What are the natural defenses of skin?

Answer 5

• Keratin
• Skin sloughing
• Sebum
• Sweat

Question 6

How is sweat a natural defense?

Answer 6

Low pH, high salt, produces lysozyme which breaks down peptidoglycan and RNase which can digest the RNA

Question 7

Describe Measle’s lesions in oral mucosa

Answer 7

Koplik’s spots appear

Question 8

Measle’s infection is through

Answer 8

aerosol droplets

Question 9

What is the rash like on measle’s?

Answer 9

Macular rash with raised spots, rash befins on face and affects the trunk and extremities

Question 10

What is the leading cause of vaccine preventable death in children?

Answer 10

Measles

Question 11

What does measles cause?

Answer 11

Pneumonia, diarrhea, encephalitis and corneal scarring

Question 12

What is German measles?

Answer 12

Rubella, caused by togavirus

Question 13

What is Congenital Rubella Syndrome?

Answer 13

Rubella virus that infects placenta and spreads to fetus and alters function of multiple fetal systems by interfering with organ formation and causing systemic inflammation

Question 14

Virulence factor of measles

Answer 14

Syncytium formation (suppresses cell mediated immunity)

Question 15

Herpesvirus have a core of souble-stranded DNA surrounded by

Answer 15

a protein coat that exhibits icosahedral symmetry

Question 16

Cold sores caused by

Answer 16

HHV 1 or 2

Question 17

HHV 1 can remain latent in

Answer 17

trigeminal nerve ganglia

Question 18

Herpetic whitlow

Answer 18

Primary lesion on the fingers or thumb of the
toddler with herpetic stomatitis, due to
autoinoculation.

Question 19

Eczema herpeticum

Answer 19

Severe form of cutaneous herpes. It may occur in
children and adults with atopic eczema.

Question 20

VZV infects the human host when

Answer 20

virus particles reach mucosal epithelial sites of entry

Question 21

Molluscum Contagiosum (MCV) is

Answer 21

a common and
very contagious human-to-human transmitted
viral infection that affects the skin causing lesions
or pustules.

Question 22

The rash of molluscum contagiosum is
characterized by

Answer 22

discrete, 2 to 5 mm papules that
are flesh-colored and dome-shaped with a
central, sharply depressed center, or umbilication.