0604 - Effector and memory T cell - EG Flashcards Preview

B1 Foundation Block > 0604 - Effector and memory T cell - EG > Flashcards

Flashcards in 0604 - Effector and memory T cell - EG Deck (20):
1

Give an example of a disease to which adaptive immune response can be life long.

adaptive memory to measles via either vaccination or infection results in lifelong immunity.

2

What are the four characteristics of memory (immune)?

quantitative (more memory than niave cells to a specific antigen), qualitative (more readily converted to effectors), altered recirculation (from lymphoidal tissue to non-lymphoidal), long-lived.

3

What is dendritic cell licencing?

Often dendritic cells need to be conditioned by the CD4 response in order to be able to equip the DC to activate a CD8 cell properly

4

What are the 3 phases of lymphocyte development from their activation due to stimulus to immune memory formation?

Expansion phase with mass clonal expansion to eradicate the pathogen; contraction phase to reduce lymphocyte count post resolution; residual memory cells to be able to elicit effective response on secondary exposure.

5

What chemokine receptor maintains lymphocytes in their lymphoid organs?

CCR7

6

What is STAT? What do they do?

acronym for signal transduction and activation of transcription. STAT signal downstream of receptor, phoshporylate, form dimers, and then enter nucleus to regulate transcription.

7

What is the signature cytokine of Th1 cells?

interferon-gamma

8

What is the signature cytokine of Th2 cells?

IL-4

9

What are Th1 cells particularly good at activating?

inflammatory response, macrophages, and dendritic cells to kill intracellular pathogens.

10

What cytokine stimulates the differentiation of a T cell to a Th1 cell?

IL-12; receptor signals to STAT4

11

What is the master regulator gene that causes T cell differentiation to Th1?

T-bet

12

List some actions of Th2 cells

activation of B cell proliferations, stimulate eosinophil recruitment and activation, stimulate mucosal secretion (e.g. of goblet cells)

13

What molecules help the differentiation of a T cell to a Th2 cell?

IL-2 (STAT5) and IL-4 (STAT6)

14

What is the master regulator gene that causes T cell differentiation to Th2?

GATA3

15

What IL activates mast cells by which Th cell?

IL-9 of Th2 activates mast cells

16

What IL activates eosinophils by which Th cell?

IL-5 of Th2 activates eosinophils

17

What is the function of Th17 cells?

recruit and activate neutrophils, stimulate epithelial cells such as keratinocytes to secrete beta-defensins, act against extracellular bacteria and fungi.

18

What is the master regulator gene that causes T cell differentiation to Th17? What activates this?

ROR-gamma-t, activated by STAT3 (STAT3 activated by secretion of IL6 and IL-!beta cytokines by DC)

19

What is the master regulator gene that causes T cell differentiation to Tfh?

Bcl-6

20

What is the master regulator gene that causes T cell differentiation to Tregs?

FoxP3

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