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Flashcards in 1. Blood Borne Viruses Deck (49)
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1

Definition of hepatitis

Inflammation of the liver

2

Types of hepatitis viruses (6)

Hep A
Hep B
Hep C
Hep D
Hep E
GBV-C (formerly Hep G)

3

Transmission of Hep A

Faecal-oral route

4

Transmission of Hep B (3)

Parenteral
Sexual
Perinatal

5

Transmission of Hep C (3)

IV drug use
Blood and blood products
Sexual

6

Transmission of Hep D

Blood-to-blood contact if Help B present

7

Transmission of Hep E

Faecal-oral route

8

Hep B particles (3)

Dane particle
Spherical
Filamentous

9

What is the Dane particle comprised of

Complete virion

10

Clinical course of acute Hep B (3)

Infection
Incubation period
Clearance of antigens and creation of anti-HBs after 6mths

11

Length of incubation period of Hep B

2-3 months

12

Definition of incubation period

Period between exposure to an infection and the appearance of the first symptoms

13

Hep B symptoms (3)

Usually none
Flu-like illness
Jaundice

14

Clinical course of chronic Hep B (3)

Infection
Incubation period
Persistence of HBsAg, no anti-HB development

15

When is HBV considered chronic

When an antibody to the core Ag is present, but there is no antibody to HBsAg (surface antigen)

16

Testing method for acute Hep B (2)

IgM anti-core - positive
HBsAg - positive/negative (still developing)

17

Testing method for chronic Hep B (3)

IgM anti-core - negative
HBsAg - positive
IgG anti-core - positive/negative

18

Test results if Hep B, previous infection (3)

IgG anticore - positive
HBsAb - positive/negative
Negative for other markers

19

Test results if Hep B vaccinated (2)

HBsAb - positive
Negative for other markers

20

Reasons for HBV vaccine (3)

Some countries as part of childhood vaccination
HCWs who perform exposure prone procedures
Highly immunogenic

21

When is post-exposure prophylaxis (PEP) not required for HBV

For those who had a successful response to the vaccine

22

Definition of prophylaxis

Treatment given or action taken to prevent disease

23

Treatment for unvaccinated HBV exposure (2)

HBIG x1 (initiated Hep B vaccine series)

24

Treatment for vaccinated non-responder for HBV exposure (2)

HBIG x1
Vaccine booster

25

HBV treatment

Antiviral drugs
Immunomodulatory agents
Oral nucleoside analogues
Nucleotide analogues

26

What is a marker of a highly infectious disease/individual

HBeAg
(Creation of antibodies against HBsAg leads to immunity when anti-HBeAg is present)

27

Clinical course of HCV infection (2)

Infection
Incubation period

28

HCV incubation period

Up to 26wks (mean is 6-12wks)

29

HCV symptoms (2)

Symptomless
Non-specific symptoms
Jaundice

30

HCV testing methods (4)

Anti-HCV test (detects antibodies presence)
HCV-RNA test (identifies virus in blood)
Viral load/quantitative HCV test (measures viral particles in peripheral blood)
Vital genotyping (type of HCV present)