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Flashcards in 4. Dental Relevance of HIV Deck (14)
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1

Definition of HIV

Human Immunodeficiency Virus

2

Definition of AIDS (4)

Acquired Immunodeficiency Syndrome
Defined as the presence of one of 25 conditions indicative of severe immunosuppression
HIV infection of an individual with a CD4+ count of <200 cells per cubic millimetre of blood
End point of an infection that is continuous, progressive and pathogenic

3

Treatment of HIV (2)

ART
HAART

4

Clinical features of AIDS (3)

Acute primary infection (seroconversion, glandular fever-like illness)
Symptomless (latent period)
Symptomatic stage (ARC, AIDS)

5

Definition of ARC

AIDS related complex

6

Types of lesions seen in HIV infection (3)

Group 1 - strongly associated
Group 2 - less commonly associated
Group 3 - seen in HIV infection

7

Types of group 1 lesions (5)

Candidosis (erythematous, pseudomembranous)
Hairy leucoplakia
NHL
Periodontal disease (linear gingiva erythema, NUG, NUP)
Parotid enlargement

8

Key stages in HIV replicative cycle (5)

HIV releases contents into target cell
Reverse transcriptase copies viral RNA into DNA
Viral DNA is inserted into cellular DNA
Many copies of viral RNA and proteins are made
New viral particles assemble and bud from cell, potentially killing it

9

Sources of HIV (5)

Saliva
Blood
Semen
Vaginal secretions
Breast milk

10

HIV transmission (4)

Sexual
Parenterally (infected blood/blood products)
Needle sharing (drug users)
In utero from mother to child (perinatally or via breast milk)

11

Lab diagnosis of HIV (4)

Serology
Viral culture
Viral antigen (p24)
Viral nucleic acid

12

AIDS management (4)

Treat opportunistic infections
Treat Kaposi sarcoma and other malignancies
ART
Supportive medicine

13

HIV management (3)

Direct viral (PCR)
Direct sequencing
Viral load quantification (detection of viral RNA)
Viral drug resistance

14

HAART involves (3)

Binding/fusion of inhibitors Reverse transcriptase inhibitors (nucleoside analogs, non-nucleoside analogs)
Protease inhibitors