1-OTC painkillers Flashcards
(37 cards)
What are prostaglandins
sensitive nociceptors to the effects of other pain-causing stimuli
which NSAID is not anti-inflammatory
acetaminophen
name 5 examples of OTC NSAIDS
naproxen (aleve), ibuprofen (advil), acetylsalicytic acid (bayer aspirin), acetominophen (tylenol), diclofenac (voltaren)
what do CGRP and Substance P do
cause vasodilation and histamine release
what is the prostaglandin synthesis pathway
arachidonic acid released from cell membranes
COX enzymes turn them into PGH2
then they get isomerated into different compounds (TxA2, PGE2…)
A.A –COX12–> Prostaglandins
which COX promotes gastric mucous secretion
COX 1
which COX promotes inflammation
COX 2
which COX promotes platelet aggregation and vasoconstriction of vessels
COX 1
which COX is known for the good side effects of inhibition by NSAIDS
COX 2
which COX is known for the bad side effects of inhibition by NSAIDS
COX 1
first NSAID sold
acetylsalicytic acid (aspirin)
NSAID Structure (3 things)
weak acid with carboxy group, hydrophobic, non-specific
why is it good that NSAIDS are hydrophobic
allows them to enter active sites
what class is aspirin in
salicylate
what class is ibuprofen in
propionic
what class acetaminophen
aminophenol
what class diclofenac
acetic acid
what class naproxen
propionic
how does aspirin work
irreversibly modifies COX enzymes by donating acetyl group to ser529 (cox1) and ser516(cox2)
what are other NSAIDS competitive inhibitors of
arachidonic acid
what do interleukins do
released from immune, induces COX2 in CNS and results in PGE2 formation
where are PGE2 receptors found
hypothalamus
what does PGE2 activation in hypothalamus cause
fever
how do NSAIDS stop fever
dont let COX2 make PGE2 (interleukin pathway)
