10. Neoplasia Flashcards Preview

Goljan > 10. Neoplasia > Flashcards

Flashcards in 10. Neoplasia Deck (23):
1

What is a hamartoma?

Overgrowth of tissue that is normally there in that area

2

What makes a cell cancerous in terms of mitosis?

Atypic mitotic spindle (aneuploid) - has nothing to do with rate

3

How many doubling times (cell cycles) does it take to get a tumor that is detectable clinically?

30

4

How do carcinomas in general metastasize?

Lymphatics first before they become hematogenous- subcapsular sinus of local lymph node

5

How do sarcomas in general metastasize?

Go straight to blood (don't like going to lymph nodes)

6

Which thyroid carcinoma likes to spread hematogenously?

Follicular

7

What is analogous in a woman to where the prostate is in a man?

Pouch of Douglas

8

What is the most common metastasis to the liver?

Lung > colon

9

Where would a testicular cancer metastasize to first?

Para-aortic lymph nodes

10

Left supraclavicular node - where is the primary?

Stomach cancer (Virchow's node)

11

What cancer makes blastic lesions in bone?

Prostate

12

Old man with lower back pain - next step in management?

Digital rectal exam - BEFORE PSA

13

Multiple lesions on gross specimen indicate what?

Metastasis!

14

What is the most common cancer in the brain?

Metastasis from lung

15

What is the most common cancer in the adrenal?

Metastasis from lung

16

Desmin stains what?

Muscle

17

Ras and p53 are what kind of mutation?

Point mutation

18

What do you treat APML with?

Retinoic acid (vitamin A) - matures the blasts

19

What is a major risk factor for bladder cancer?

Smoking and aniline dyes

20

What cancer is HIV associated with?

Primary CNS lymphoma

21

What is the most common radiation induced cancer?

Leukemia (specifically CML)

22

What type of UV light gives you cancer?

UV-B

23

What cancer does actinic keratosis predispose to?

Squamous cell