11a. Neoplasia Flashcards Preview

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Flashcards in 11a. Neoplasia Deck (27):
1

What's the defect in xeroderma pigmentosum?

DNA repair

2

Skin cancer - upper lip?

Basal cell

3

Skin cancer - lower lip?

Squamous cell

4

What is the only bacteria associated with cancer?

H pylori

5

What are the 2 cancers associated with H pylori?

Adenocarcinoma and low grade (MALT) lymphoma

6

What's the most important prognostic factor in the TNM staging system?

M - metastasis (TNM goes in order of importance)

7

What platelet abnormality do most cancer patients have?

Thrombocytosis

8

What is the most common cause of fever in cancer patient?

Gram-negative bacteria (usually nosocomial)

9

Most common paraneoplastic syndrome?

Hypercalcemia

10

What are 2 mechanisms of hypercalcemia in malignancy?

1. Metastasis to bone
2. PTH-related peptide (this one is paraneoplastic)

11

Acanthosis nigricans is typically indicative of what cancer?

Gastric (acanthosis nigricans is associated with other things but consider gastric adenocarcinoma)

12

Clubbing is associated with what cancer?

Primary lung cancer

13

Elevated CK and raccoon eyes?

Dermatomyositis

14

Hyponatremia or Cushing's - cancer?

Small cell cancer in the lung

15

Hypercalcemia or 2 polycythemia vera - cancer?

Renal cell carcinoma

16

Hypocalcemia or Cushing's - cancer?

Medullary carcinoma of the thyroid

17

What 2 tumor markers do you get with testicular cancer?

Alpha fetal protein and hCG

18

Alpha fetal protein decreased in pregnancy?

Down syndrome

19

Alpha fetal protein increased in pregnancy?

Neural tube defect

20

What is a tumor marker for colon cancer?

CEA

21

Primary tumor of the brain in kids?

Pilocytic astrocytoma (benign)

22

Primary cancer of the brain in kids?

Medulloblastoma (malignant)

23

Most common cancer in kids?

ALL

24

Most common GYN cancer?

Endometrial > ovarian > cervical

25

Why is cervical cancer the least common GYN cancer?

Pap smear

26

What are the rates of mortality for GYN cancers?

Ovarian > cervical > endometrial

27

What is the only tumor you can vaccinate against?

Hepatocellular because you vaccinate against Hep B and you also won't get Hep D (3 for 1 vaccine!)