15. Hematology Flashcards Preview

Goljan > 15. Hematology > Flashcards

Flashcards in 15. Hematology Deck (31):
1

What is heterophile positive?

EBV

2

Is eosinophilia associated with protozoans?

No, only invasive worms

3

What is RBC mass vs. RBC count?

RBC mass = total RBC's, RBC count = per unit of volume

4

Relative polycythemia?

Decrease in volume but RBC mass is actually normal

5

2 things to consider with inappropriate polycythemia?

1. Polycythemia vera - neoplastic process of stem cell
2. Tumor or cyst with excess EPO production

6

Myeloproliferative diseases?

1. Polycythemia vera
2. CML
3. Essential thrombocythemia
4. Myelodysplastic syndrome
5. Myelofibrosis

7

Why does polycythemia lead to increased risk of thrombosis?

Increased viscosity and increased peripheral resistance

8

How does polycythemia vera affect volume status?

Hypervolemia - only polycythemia that does this

9

Patient with polycythemia - itch after shower why?

Mast cells in the skin; temperature causes degranulation leading to generalized itching (histamine)

10

What is the epo level in polycythemia vera and why?

Low because you have plenty of RBC's, normal O2 sat which negatively feeds back on epo production

11

Blast count - acute vs. chronic?

over 30% is acute

12

Age under 15 - leukemia?

ALL

13

Age 15- 39 - leukemia?

AML - blast with Auer Rods

14

Age 40 - 59 - leukemia?

AML and CML (differentiate with blast % in the marrow)

15

Age 60 and over - leukemia?

CLL

16

What can you use to test for CML besides bcr-abl?

Low alkaline phosphatase

17

Splenomegaly with tear drop cell?

Myelofibrosis with myelodysplasia

18

CD10+ B cell?

CALLA antigen that is marker for B cell ALL

19

TRAP +?

Hairy cell leukemia

20

What do we look for on AML histology?

Auer rods

21

What leukemia is associated with DIC?

AML because of the Auer rods

22

Treat AML with?

Vitamin A

23

What does vitamin A do in AML?

Matures the blast cells

24

What is the translocation in AML?

t(15,17)

25

Painful lymphadenopathy?

NOT cancer, indicative of inflammation

26

Painless lymphadenopathy?

Cancer - lymphoma or metastasis

27

What's in a lymph node follicle?

B cells

28

What two tissues are resistant to invasion by cancer?

Cartilage and elastic tissue

29

What is the neoplastic cell in mycosis fungoides?

CD4+ helper T cells

30

What do we call mycosis fungoides that goes to the blood?

Sezarry syndrome

31

CD1+ cell in clonal proliferation on blood smear?

Langerhans histiocytosis