Flashcards in 15. Hematology Deck (31):
What is heterophile positive?
Is eosinophilia associated with protozoans?
No, only invasive worms
What is RBC mass vs. RBC count?
RBC mass = total RBC's, RBC count = per unit of volume
Decrease in volume but RBC mass is actually normal
2 things to consider with inappropriate polycythemia?
1. Polycythemia vera - neoplastic process of stem cell
2. Tumor or cyst with excess EPO production
1. Polycythemia vera
3. Essential thrombocythemia
4. Myelodysplastic syndrome
Why does polycythemia lead to increased risk of thrombosis?
Increased viscosity and increased peripheral resistance
How does polycythemia vera affect volume status?
Hypervolemia - only polycythemia that does this
Patient with polycythemia - itch after shower why?
Mast cells in the skin; temperature causes degranulation leading to generalized itching (histamine)
What is the epo level in polycythemia vera and why?
Low because you have plenty of RBC's, normal O2 sat which negatively feeds back on epo production
Blast count - acute vs. chronic?
over 30% is acute
Age under 15 - leukemia?
Age 15- 39 - leukemia?
AML - blast with Auer Rods
Age 40 - 59 - leukemia?
AML and CML (differentiate with blast % in the marrow)
Age 60 and over - leukemia?
What can you use to test for CML besides bcr-abl?
Low alkaline phosphatase
Splenomegaly with tear drop cell?
Myelofibrosis with myelodysplasia
CD10+ B cell?
CALLA antigen that is marker for B cell ALL
Hairy cell leukemia
What do we look for on AML histology?
What leukemia is associated with DIC?
AML because of the Auer rods
Treat AML with?
What does vitamin A do in AML?
Matures the blast cells
What is the translocation in AML?
NOT cancer, indicative of inflammation
Cancer - lymphoma or metastasis
What's in a lymph node follicle?
What two tissues are resistant to invasion by cancer?
Cartilage and elastic tissue
What is the neoplastic cell in mycosis fungoides?
CD4+ helper T cells
What do we call mycosis fungoides that goes to the blood?