16. Hematology Flashcards Preview

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Flashcards in 16. Hematology Deck (26):
1

Woman with lymph node involvement - anterior mediastinum and one other location above the diaphragm?

Hodgkin's disease

2

What's the most abundant gammaglobulin?

GAMmaglobulin: IgG > IgA > IgM

3

Polyclonal gammamopathy?

Benign, chronic inflammation

4

Monoclonal gammamopathy?

Malignancy of plasma cell (usually IgG)

5

Light chains in the urine?

Bence Jone proteins

6

Why are Down syndrome patients at increased risk of Alzheimer's?

Extra chromosome 21 making extra beta amyloid

7

Macrophage looks like it has crinkly paper inside

Gaucher's - accumulation of glucocerebroside

8

What is the only glycogen storage disease that is a lysosomal storage disease?

Pompe - deficiency of lysosomal alpha 1,4 glucosidase with build up of glycogen in the lysosome

9

Where is ATIII made?

Liver

10

How does Heparin work?

Potentiates ATIII

11

What do Protein C and S do?

Inactivate Factor V and VIII

12

Why do we need Proteins C and S?

ATIII only inactivates serine proteases - cannot inactivate Factor V and VIII

13

Woman on OCP and smoking?

HUGE risk of thrombosis

14

Bleeding time deals with what?

Platelet function - NOTHING to do with coagulation factor

15

Where is vWF found?

Platelets and endothelial cells

16

What is the point of vWF?

Adhesion molecule - lets platelets stick

17

What does vWF cause platelets to release?

ADP - promotes aggregation

18

What is the most important chemical for platelet aggregation?

Thromboxane A2

19

What does thromboxane A2 and how is this important to platelet function?

Potent vasoconstriction - slows blood flow so the platelets can stick together

20

What are the 3 functions of thromboxane A2?

1. vasoconstriction
2. bronchoconstriction
3. platelet aggregation

21

What's the difference between aspirin and NSAIDs?

Aspirin is irreversible, NSAIDs is reversible

22

Menorrhagia - platelet or coag factor problem?

Coag factor

23

Hemarthrosis - platelet or coag factor problem?

Coag factor

24

Petechiae - platelet or coag factor problem?

Platelet

25

Ristocetin co-factor assay?

Tells you that vWF problem

26

Arthritis patient comes in bleeding but all normal tests - what's going on?

Normal platelet count but he's on NSAID's so platelets aren't aggregating