Flashcards in 16. Hematology Deck (26):
Woman with lymph node involvement - anterior mediastinum and one other location above the diaphragm?
What's the most abundant gammaglobulin?
GAMmaglobulin: IgG > IgA > IgM
Benign, chronic inflammation
Malignancy of plasma cell (usually IgG)
Light chains in the urine?
Bence Jone proteins
Why are Down syndrome patients at increased risk of Alzheimer's?
Extra chromosome 21 making extra beta amyloid
Macrophage looks like it has crinkly paper inside
Gaucher's - accumulation of glucocerebroside
What is the only glycogen storage disease that is a lysosomal storage disease?
Pompe - deficiency of lysosomal alpha 1,4 glucosidase with build up of glycogen in the lysosome
Where is ATIII made?
How does Heparin work?
What do Protein C and S do?
Inactivate Factor V and VIII
Why do we need Proteins C and S?
ATIII only inactivates serine proteases - cannot inactivate Factor V and VIII
Woman on OCP and smoking?
HUGE risk of thrombosis
Bleeding time deals with what?
Platelet function - NOTHING to do with coagulation factor
Where is vWF found?
Platelets and endothelial cells
What is the point of vWF?
Adhesion molecule - lets platelets stick
What does vWF cause platelets to release?
ADP - promotes aggregation
What is the most important chemical for platelet aggregation?
What does thromboxane A2 and how is this important to platelet function?
Potent vasoconstriction - slows blood flow so the platelets can stick together
What are the 3 functions of thromboxane A2?
3. platelet aggregation
What's the difference between aspirin and NSAIDs?
Aspirin is irreversible, NSAIDs is reversible
Menorrhagia - platelet or coag factor problem?
Hemarthrosis - platelet or coag factor problem?
Petechiae - platelet or coag factor problem?
Ristocetin co-factor assay?
Tells you that vWF problem