10.1 Study Guide

Question 1

List the order of the cell cycle:

Answer 1

1. G1(Interphase)—>G0
2. S(Interphase)
3. G2(Interphase)
4. M(Mitosis)

Question 2

Name stimulatory proteins:

Answer 2

Growth Factors(small proteins), APC/C, CDKs(cyclin-dependent kinases), cyclins, proto-oncogenes.
They move the cell into the next stage of the cell cycle.

Question 3

Name inhibitory proteins:

Answer 3

MAD, BRCA1, ATM, Rb, tumor suppressor genes, p53.
They stop the cell from continuing on to the next stage of the cell cycle and prevent the activation of CDK-cyclins.

Question 4

What do proto-oncogenes do?

Answer 4

Stimulate the cell cycle.

Question 5

What do tumor suppressor genes do?

Answer 5

Inhibit the cell cycle.

Question 6

Why do mutations of proto-oncogenes and tumor suppressor genes cause cancer?

Answer 6

Mutated oncogenes speed up and increase stimulation extensively, Mutated tumor suppressor genes cause the loss of inhibition.