African Sleeping Sickness

Question 1

What are the causative organisms of African Sleeping Sickness?

Answer 1

Trypanosoma brucei subspecies. gambiense or rhodesiense

Question 2

What are Trypanosoma brucei subspecies gambinese or rhodesiense?

Answer 2

Prions

Question 3

What are the most common modes of transmission?

Answer 3

Vector, vertical

Question 4

What are the virulence factors for Trypanosoma brucei subspecies gambienses or rhodesiense (Afrrcan Sleeping Sickness)?

Answer 4

Immune evasion by antigen shifting

Question 5

How do you culture/diagnose Trypanosoma brucei subspecies gambiense or rhodesiense (African Sleeping Sickness)?

Answer 5

Microscopic examination of blood, CSF

Question 6

How do you prevent Trypanosoma brucei subspecies gambiense or rhodesiense (African Sleeping Sickness) infection?

Answer 6

Vectorr control

Question 7

How do you treat Trypanosoma brucei subspecies gambiense or rhodesiense (African Sleeping Sickness) infection?

Answer 7

Suramin or pentamidine (early), eflornithine or melarsoprol (late)

Question 8

What are the epidemiological features of Trypanosoma brucei subspecies gambiense or rhodesiense?

Answer 8

T. brucei gambiense: 7,000-10,000 cases reported annually; actual occurrence estimated at 600,000;
T. brucei rhodesiense: estimated 30,000 cases occur annually