RNA VIRUS - PARAMYXOVIRIDAE - Measles virus Flashcards
Enveloped, helical, non-segmented ss-negative RNA
measles virus
Pathogenesis of measles
measles virus infects the cells lining the URTI – enters BLOOD – infects REC – spreads via the blood to the skin – CYTOTOXIC T CELLS attack the measles virus-infected vascular endothelial cells in the skin – RASH – virus can no longer be recovered – patient can no longer spread virus to other
Incubation period of measles
10-14 days
Period of communicability of measles
4 days BEFORE and 4 days AFTER the onset of the rash
Pathognomonic enanthem pf measles
Koplik’s spots
Bright red lesions w/ a white central dot on the buccal mucosa
Koplik’s spots
Timing of appearance of rash in measles
height of the fever
cephalocaudal appearance of maculopapular rash - FACE – TRUNK – EXTREMITIES – PALMS/SOLES
Rash fades in the same sequence in which it appears
BRANNY DESQUAMATION
Complications of Measles
Otitis Media
Giant Cell Pneumonia, Secondary Bacterial Pneumonia
Higher rate of activation of PTB
Subacute Sclerosing Panencephalitis (SSPE/Dawson Disease)
Neurodegenerative disease caused by persistent infection of the brain by an altered form of the measles virus
Manifests 5-7 years after initial infection
Subacute Sclerosing Panencephalitis (SSPE/Dawson Disease)
Final common pathway to a fatal outcome in measles
Bronchiolitis obliterans
Inclusion bodies in Measles
WARTHIN FINKELDAY BODIES - multinucleated giant cells
multinucleated giant cells which form as a result of the FUSION PROTEIN in the SPIKES
WARTHIN FINKELDAY BODIES
Can reduce morbidity and mortality from measles particularly in malnourished children
VITAMIN A
Cardinal manifestations of Measles
Cough
Coryza
Conjunctivitis
C(K)oplic spots
