RNA VIRUS - FLAVIRIDAE - Dengue virus

Question 1

Enveloped, icosahedral, non-segmented, (+) ssRNA

Answer 1

Dengue virus

Question 2

4 serotypes of Dengue

Answer 2

Den - 1,2,3,4

Question 3

Transmission of dengue

Answer 3

Bite of female Aedes aegypti, Aedes albopictus

Question 4

Influenza like syndrome characterized by BIPHASIC FEVER, MYALGIA, ARTHRALGIA

Answer 4

Dengue Fever ( Breakbone fever)

Question 5

Severe often fatal febrile disease

capillary permeability
abnormalities of homeostasis
protein losing shock syndrome

Answer 5

Dengue Hemorrhagic Fever

Question 6

Detect gene product (NS-1 glycoprotein) from day 1 until day 6 from the onset of fever

Answer 6

NS1 Antigen

Question 7

Detect dengue viral genes (RNA) in acute phase serum samples which coincide with the onset of viremia

Answer 7

RT-PCR

Question 8

Marker of RECENT infection

Answer 8

Dengue IgM

Question 9

Marker of past infection

Answer 9

Dengue IgG

4FOLD increase confirms the diagnosis

Question 10

Complete Blood Count and Platelet Count Findings

Answer 10

Thrombocytopenia w/ Leukopenia

hematocrit level increase > 20%

Question 11

Dengue Vaccine (Dengvaxia)

Answer 11

LIVE RECOMBINANT TETRAVALENT dengue vaccine

given as 3 dose series

0/6/12

Question 12

The MC insect borne viral disease in the world

Answer 12

Dengue