Th - PET in response monitoring and prediction Flashcards
1
Q
What does the time course and magnitude of uptake depend on in PET pharmacokinetic modelling? (2)
A
Input function and kinetic behaviour of tissue/tumor
2
Q
What are two challenges in PET kinetic analysis? (2)
A
1.Assessment of most appropriate (accuracy and precision) kinetic model, parametric method or simplified approach
2.Find accurate and non-invasive methods for extracting / obtaining input functions, either plasma input or reference tissue, reduce scan time
3
Q
Why quantify tracer uptake in PET monitoring? (2)
A
To compare patients, also for longitudinal studies
