Mo - Phosphoproteonomics for target discovery and personalized medicine

Question 1

What is proteomics?

Answer 1

Large scale analysis of proteins

Question 2

True or false: Multiple genomics and post-genomic aberrations determine cancer phenotype

Answer 2

True

Question 3

What is mass spectrometry? What is it used for?

Answer 3

The weighing of molecules, used for determining which proteins are which

Question 4

How is phosphoproteonomics used in cancer? (2)

Answer 4

To identify drug targets, to reveal heterogeneity of cancer cell lines

Question 5

How can phosphoproteomics be used in personalized medicine?

Answer 5

To determine which patients have certain kinase mutations and are thus candidates for targeted therapy

Question 6

How can phosphoproteomics be used specifically in T-cell acute lymphoblastic leukaemia? (Explain complicated)

Answer 6

Phosphoproteomics can identify targetable kinases, upon which Inhibition of the INSR/IGF-1R axis can sensitize T-cell acute lymphoblastic leukaemia cells to dastinib treatment