Erythrocytosis

Question 1

Erythrocytosis

Answer 1

Increase Hct, Hgb, or RBC concentrations

Question 2

Hemoconcentration

Answer 2

Increase concentration of blood components (including RBC) because plasma volume is low

Question 3

Dogs with normal higher PCV

Answer 3

Greyhounds, Afghan hounds, whippets

Question 4

Types of erythrocytosis

Answer 4

1. Relative (dehydration or redistribution
2. Absolute
   -Primary
   -Secondary

Question 5

Relative erythrocytosis

Answer 5

Total body red cell mass is normal but measured RBC parameters are increased. Usually from dehydration or from redistribution in catecholamine release and splenic contraction

Question 6

Absolute erythrocytosis

Answer 6

Increased in RBC mass resulting from increased erythropoiesis. Plasma protein concentration is normal and not dehydrated

Question 7

Primary absolute erythrocytosis

Answer 7

Independent of EPO (no stimulus)
Myeloproliferative disease neoplastic process where producing RBC despite no EPO signal

Question 8

Secondary absolute erythrocytosis

Answer 8

Increased Epo production
-Appropriate-> due to chronic tissue hypoxia
-Inappropriate-> independent of tissue hypoxia

Question 9

Mechanisms of inappropriate Epo production

Answer 9

-Renal abnormalities
-Neoplasia
-Endocinopathies

Question 10

Consequences of erythrocytosis

Answer 10

Increased blood viscosity-> sluggish blood flow increase risk of thrombosis, decreased O2 to brain
Increased blood volume-> contribute to HF

Question 11

Clinical signs of erythrocytosis

Answer 11

Hyperemic skin and mucous membranes
Splenomegaly (uncommon)
Neuro disturbances
May see microcytosis