Alcohol Related Fatty Liver Disease

Question 1

stages of ARFLD

Answer 1

steatosis
alcoholic hepatitis
fibrosis
cirrhosis

Question 2

brief pathophysiology of ARFLD

Answer 2

alcohol converted to acetaldehyde
NAD+ –> NADH : increasd production of fatty acids and decreased oxidation

increased ROS due to ethanol breakdown, cause damage

neutrophils infiltrate
inflammation and damage lead to fibrosis

Question 3

what immunoglobulin can be raised in ARFLD

Answer 3

IgA

Question 4

what may the LFTs show in ARFLD

Answer 4

Increased ALT, significantly increased AST
AST: ALT > 2
(increased ALP and GGT)

Question 5

other blood abnormalities which can be seen in bloods of ARFLD

Answer 5

macrocytic anaemia
thrombocytopenia
hypoglycaemia

Question 6

management of ARFLD

Answer 6

alcohol abstinence

later stages involve steriods for immunosuppression to prevent further damage of the liver