18-2

Question 1

Hepatitis A

Answer 1

RNA
Fecal - oral; Contaminated raw shellfish
Acute

Question 2

What is the incubation period for Hepatitis A?

Answer 2

2-6 weeks

Question 3

When is HAV shed in the stool?

Answer 3

2-3 weeks before and 1 week after onset of jaundice

Question 4

Symptoms of Hepatitis A?

Answer 4

Fatigue, loss of appetite, jaundice

- Rash, arthralgia, immune complex mediated complications

Question 5

Symptoms of Hepatitis A?

Answer 5

Fatigue, loss of appetite, jaundice

- Rash, arthralgia, immune complex mediated complications

Question 6

What marker is (+) for Hepatitis A?

Answer 6

IgM

Question 7

Hepatitis B

Answer 7

DNA
Blood; Needles; MOTHER TO BABY (vertical)
Rarely chronic

Question 8

What is the incubation period for Hepatitis B?

Answer 8

2-26 weeks

Question 9

What are the 4 main presentations for Hepatitis B infection?

Answer 9

1. Acute Hepatitis –> recovery
2. Acute liver failure with massive necrosis
3. Chronic Hepatitis w/ or w/o cirrhosis
4. Asymptomatic carrier

Question 10

What are the 4 main presentations for Hepatitis B infection?

Answer 10

1. Acute Hepatitis –> recovery
2. Acute liver failure with massive necrosis
3. Chronic Hepatitis w/ or w/o cirrhosis
4. Asymptomatic carrier

Question 11

What markers will be (+) with Hepatitis B?

Answer 11

(+) HBV DNA
(+) HBsAg
(+) HBcAg antibodies

Question 12

What does the outcome of Hepatitis B infection depend on?

Answer 12

Immune response

Question 13

Resolution is more likely with Hepatitis B infection if what immune response occurs?

Answer 13

CD4 and CD8 T cells release IFN-gamma

Question 14

Hepatitis C

Answer 14

RNA
Blood; needles
CHRONIC

Question 15

What is the incubation period for Hepatitis C?

Answer 15

4-26 weeks

Question 16

Symptoms of Hepatitis C?

Answer 16

Asymptomatic

Question 17

Symptoms of Hepatitis C?

Answer 17

Asymptomatic

Question 18

Lab markers for Hepatitis C?

Answer 18

Fluctuating AST/ALT is seen with Chronic HCV

Question 19

What types of things can cause progression of HCV towards chronic HCV and cirrhosis?

Answer 19

Older males, alcohol, obesity and diabetes

Question 20

What is the reason that many are unable to eradicate HCV infection?

Answer 20

Genetic variants

Question 21

Morphology of ACUTE viral hepatitis?

Answer 21

Lymphocyte, plasma cell and eosinophil inflammatory infiltrate

Question 22

Morphology of ACUTE viral hepatitis?

Answer 22

Lymphocyte, plasma cell and eosinophil inflammatory infiltrate

Question 23

Necrosis or Apoptosis of hepatocytes with ACUTE viral hepatitis may occur. What quality of macrophages will be seen?

Answer 23

Pigmented

Question 24

Main morphologic sign with CHRONIC viral hepatitis?

Answer 24

Portal lymphocytic inflammation with fibrosis and scarring

Question 25

Main morphologic sign with CHRONIC viral hepatitis?

Answer 25

Portal lymphocytic inflammation with fibrosis and scarring

Question 26

Interface activity can be seen with CHRONIC viral hepatitis. What is that?

Answer 26

Inflammatory cells cross limiting plate and injure periportal hepatocytes

Question 27

Interface activity can be seen with CHRONIC viral hepatitis. What is that?

Answer 27

Inflammatory cells cross limiting plate and injure periportal hepatocytes

Question 28

Due to the fibrosis that occurs with CHRONIC viral hepatitis, what usually results?

Answer 28

Cirrhosis

Question 29

Main morphologic sign of CHRONIC HBV?

Answer 29

Ground glass hepatocytes

Question 30

Ground glass hepatocytes are seen with?

Answer 30

Chronic Hepatitis B

Question 31

What are ground glass hepatocytes?

Answer 31

- seen with chronic hepatitis B | = swollen endoplasmic reticulum with HBsAg

Question 32

Main morphologic sign of CHRONIC HCV?

Answer 32

Lymphoid follicles in portal tract

Question 33

Lymphoid follicles in portal tract are seen with?

Answer 33

Chronic Hepatitis C

Question 34

Steatosis and bile duct injury are other common morphologic features of which chronic hepatitis?

Answer 34

C

Question 35

Portal lymphocytic inflammation with fibrosis and scarring is seen with what type of hepatitis?

Answer 35

CHRONIC