Surface, PGE1, Bismuth Compounds for PUD and GERD (anti-ulcer) Flashcards
(40 cards)
What is the Surface Acting Agent?
Sucralfate
What is the Surface Acting Agent?
Sucralfate
Sucralfate is a?
Surface Acting Agent
What does Sucralfate undergo to exert its MOA?
Cross-linking from interaction with stomach acid to create a sticky polymer
Sucralfate becomes a sticky polymer after cross-linking due to interaction with stomach acid. What does this do?
Adheres to epithelial cells around the ulcer’s crater
Sucralfate becomes a sticky polymer after cross-linking due to interaction with stomach acid. What does this do?
Adheres to epithelial cells around the ulcer’s crater
MOA for Sucralfate (surface acting agent)?
Adheres to epithelial cells around the ulcer’s crater
==> Prevents acid access to ulcer
What does Sucralfate prevent from accessing the ulcer?
Acid
What else can Sucralfate stimulate?
Prostaglandins, mucous and epidermal growth factor production
What is Sucralfate indicated for?
DU
Drug indicated to treat DU?
Sucralfate
Adverse effect of Sucralfate?
Constipation
What drug can cause Constipation?
Sucralfate
Does Sucralfate have drug interactions?
Possible
= Take it 2 hours after other medications
Relative Contraindications for Sucralfate?
Severe Renal Failure
= Aluminum should be avoided
What in Sucralfate should be avoided for Renal Failure patients?
Aluminum
What is a PGE1 Analog?
Misoprostol
What is a PGE1 Analog?
Misoprostol
Misoprostol is a?
PGE1 Analog
MOA for Misoprostol (PGE1 Analog)?
Provides protective prostaglandin actions and
Inhibits acid release from parietal cells
What drug class provides prostaglandin actions and inhibits acid release from parietal cells?
Misoprostol (PGE1 Analogs)
Generally, Misoprostol provides cytoprotection by?
Increasing mucosal defenses
How does Misoprostol provide cytoprotection (mucosal defenses)?
Increases bicarbonate and mucous and mucosal blood flow
PGE1 Analog (Misoprostol) is indicated for?
Prevention of NSAID-Induced Gastric Ulceration
prophylaxis
