16-3

Question 1

What is a Keratocystic Odontogenic Tumor?

Answer 1

Aggressive epithelial-lined cyst in the jaw

posterior mandible

Question 2

What is a Keratocystic Odontogenic Tumor?

Answer 2

Aggressive epithelial-lined cyst in the jaw

posterior mandible

Question 3

Who is commonly affected with Keratocystic Odontogenic Tumors?

Answer 3

Males 10-40

Question 4

What is the most common oral cancer?

Answer 4

Squamous cell carcinoma

Question 5

What is the most common oral cancer?

Answer 5

Squamous cell carcinoma

Question 6

Leukoplakia

Answer 6

White patch that canNOT be scraped off and is not due to any other disease/reason

Question 7

White patch that cannot be scraped off and is not due to any other disease/reason

Answer 7

Leukoplakia

Question 8

Leukoplakia is ____

Answer 8

Pre-cancerous

Question 9

Erythroplakia

Answer 9

Red, velvety lesion equal to or slightly below surrounding mucosa

Question 10

Red, velvety lesion equal to or slightly below surrounding mucosa

Answer 10

Erythroplakia

Question 11

Erythroplakia is ____

Answer 11

MOST pre-cancerous

Question 12

Leukoplakia and Erythroplakia are pre-cancerous. What patient population often has them?

Answer 12

Older males who use tobacco

Question 13

The etiology of Squamous cell carcinoma is multifactorial. What are the top 2 reasons?

Answer 13

1. HPV infection

2. Tobacco and alcohol use

Question 14

The etiology of Squamous cell carcinoma is multifactorial. What are the top 2 reasons?

Answer 14

1. HPV infection

2. Tobacco and alcohol use

Question 15

Instead of tobacco and alcohol, what in india/asia can cause SCC?

Answer 15

Betel nuts and paan

Question 16

What can cause cancers of the lower lip?

Answer 16

Actinic radiation and pipe smoking

Question 17

Actinic radiation and pipe smoking cause?

Answer 17

Cancers of the lower lip

Question 18

What strains of HPV are seen with oropharyngeal SCC?

Answer 18

16 and 18

Question 19

Oropharyngeal SCC affects who?

Answer 19

White males who do NOT smoke age 35-55

Question 20

Long term survival is better in patients with HPV (+) or (-) SCC?

Answer 20

HPV (+)!!

Question 21

Long term survival is better in patients with HPV (+) or (-) SCC?

Answer 21

HPV (+)!!

Question 22

What genes can be mutated with SCC?

Answer 22

TP53
CDKn2a
PIK3cA

Question 23

What genetic alterations are present with SCC?

Answer 23

NOTCH1 and FAT1

Question 24

HPV (-) tumors harbor ____ somatic mutations

Answer 24

MORE

Question 25

What proteins are present that disrupt the cell cycle with HPV (+) SCC?

Answer 25

E6 and E7

Question 26

E6 does what?

Answer 26

(-) P53

Question 27

E7 does what?

Answer 27

(-) RB

Question 28

What genes can be mutated with SCC?

Answer 28

TP53 CDKn2a PIK3cA

Question 29

What genetic alterations are present with SCC?

Answer 29

NOTCH1 | FAT1

Question 30

Classic SCC affects what parts of the oral cavity?

Answer 30

Ventral tongue Floor of the mouth Lower lip

Question 31

Classic SCC will be preceded by?

Answer 31

Leukoplakia or Erythroplakia

Question 32

Classic SCC has protruding?

Answer 32

Masses

Question 33

What causes Classic SCC?

Answer 33

Tobacco carcinogen induced

Question 34

HPV+ SCC affects what parts of the oral cavity?

Answer 34

Tonsillar crypts in lingual tonsils | Base of tongue

Question 35

HPV+ SCC will be preceded by?

Answer 35

NOTHING

Question 36

HPV+ SCC will have?

Answer 36

Small tumors with cervical LAD

Question 37

HPV+ SCC will have overexpression of what protein?

Answer 37

P16

Question 38

Proliferation of nests/lobules of basaloid and nonkeratinizing cells is seen with?

Answer 38

HPV+ SCC

Question 39

Sore throat, ear ache, odynophagia and weight loss could indicate?

Answer 39

Oropharyngeal SCC

Question 40

What is the Theory of Field Cancerization?

Answer 40

Multiple independent primary tumors develop as a result of years of chronic exposure to carcinogens

Question 41

Survival rate using the Theory of Field Cancerization?

Answer 41

5 year survival rate for 1st primary tumor is >> 2nd primary tumor

Question 42

What is the Theory of Field Cancerization?

Answer 42

Multiple independent primary tumors develop as a result of years of chronic exposure to carcinogens

Question 43

Overexpression of P16 is seen with?

Answer 43

HPV+ SCC