2.2.2 Bladder and Penile Neoplasia

Question 1

What are the clinical features of squamous cell carcinoma of the penis?

Answer 1

Question 2

What determines the prognosis of urothelial tumors?

Answer 2

Question 3

What are the characteristics of Condyloma acuminatum?

Answer 3

Benign sexually transmitted tumor caused by HPV

Related to common wart

Occurs on moist mucocutaneous surface of the external genitals of either sex

HPV 6 is most common relation

Question 4

What are the characteristics of low-grade papillary urothelial carcinomas?

Answer 4

Orderly appearance both architecturally and cytologically

Evenly spaced cohesive cells, with minimal but definitive nuclear atypia, infrequent mitosis

Good clinical course

Question 5

What is this an image of?

Answer 5

Bowen disease carcinoma in situ of the penis

Question 6

What is this an image of?

Answer 6

Squamous cell carcinoma of the penis

Question 7

What is this an image of?

Answer 7

Low-grade papillary urothelial carcinoma

Question 8

What is Bowen disease?

Answer 8

Subtype of CIS

Question 9

What are the characteristics of urothelial papilloma?

Answer 9

Question 10

What are the characteristics of invasive urothelial cancer?

Answer 10

Question 11

What is this an image of?

Answer 11

Ulcerated lesion - bladder tumor

Question 12

What are the characteristics of squamous cell carcinoma of the penis?

Answer 12

Question 13

What is this an image of?

Answer 13

High grade invasive urothelial carcinoma

Question 14

Most common age when bladder tumors arise?

Answer 14

Between 50 and 80

Question 15

What is this an image of?

Answer 15

Condyloma acuminatum of the paenis

Question 16

What are some of the symptoms of bladder tumors?

Answer 16

Painless hematuria

Frequency, urgency, and dysuria

High recurrent rate

Question 17

What is the treatment of urothelial tumors?

Answer 17

Question 18

What are the characteristics of High-grade papillary urothelial carcinoma?

Answer 18

Dyscohesive cells, with large hyperchromatic nuclei, frank anaplasia

Frequent mitotic figures, including atypical ones

Architecturally, disarray and loss of polarity

High incidence of invasion into the muscular layer

Question 19

What is Bowenoid papulosis?

Answer 19

Question 20

What type of bladder tumor is this?

Answer 20

Papillary tumor

Question 21

What are the characteristics of Carcinoma in situ or flat urothelial carcinoma?

Answer 21

Question 22

What is this an image of?

Answer 22

High-grade papillary urothelial carcinomas

Question 23

What is this an image of?

Answer 23

Urothelial papilloma

Question 24

What is this an image of?

Answer 24

Invasive urothelial carcinoma invading muscularis propria

Question 25

What are some of the predisposing factors to bladder tumors?

Answer 25

Cigarette smoking Aryl amines *Schistosoma haematobium* Analgesics Cyclophosphamide

Question 26

What are the 4 morphologic patterns of bladder tumors?

Answer 26

Question 27

What is this an image of?

Answer 27

Condyloma acuminatum

Question 28

What are the two distinct precursor lesions to Urinary bladder tumors?

Answer 28

Non-invasive papillary tumors Flat non-invasive urothelial carcinoma

Question 29

Describe the staging of bladder carcinoma

Answer 29

Ta - noninvasive, papillary Tis - Carcinoma in situ T1 - Lamina propria invasion T2 - Muscularis propria invasion T3a - Microscopic extra-vesicle invasion T3b - Grossly apparent extra-vesicle invasion T4 - Invades adjacent structures

Question 30

What is this an image of?

Answer 30

Carcinoma in situ or **flat** urothelial carcinoma