3.3.1 Benign Lesions of the Breasts

Question 1

Which growth pattern of DCIS homegirl?

Answer 1

Noncomedocarcinoma

Question 2

What this be?

Answer 2

Intraductal papilloma

Question 3

What this be?

Answer 3

Comedo DCIS

Question 4

What this be?

Answer 4

Epithelial hyperplasia w/o atypia

Question 5

What are some of the different clinical presentations of breast carcinoma?

Answer 5

Pain, palpable mass, lumpiness, nipple discharge or skin change, screen mammography

Question 6

Condition?

Answer 6

Lobular carcinoma is situ (LCIS)

Question 7

What this be?

Answer 7

LCIS

Question 8

Name this condition?

Answer 8

Papilloma

Question 9

Name this gene

Answer 9

BRCA1

Question 10

Condition?

Answer 10

DCIS

Question 11

What this be?

Answer 11

Paget’s dz

Question 12

Condition?

Answer 12

LCIS

Question 13

Left? Right?

Answer 13

Left: Papillary DCIS

Right: Mircopapillary DCIS

Question 14

Large duct papillomas are usually what? Small duct?

Answer 14

Large -> Solitary

Small -> Multiple

Question 15

What are the 3 types of benign breast lesions?

Answer 15

Non-proliferative breast changes (fibrocystic)

Proliferative w/o atypia

Proliferative w/ atypia

Question 16

What are some of the different hormonal influences that can increase risk of breast carcinoma?

Answer 16

Question 17

What this be?

Answer 17

Sclerosing adenosis

Question 18

Name this condition?

Answer 18

ADH

Question 19

Name this condition?

Answer 19

Breast carcinoma

Question 20

What are two broad categories of risk factors for breast cancer?

Answer 20

Hormonal and genetic

Question 21

Where do all carcinomas arise?

Answer 21

terminal duct lobular unit (TDLU)

Question 22

Name this condition

Answer 22

Sclerosing adenosis

Question 23

What are some of the environmental factors associated with breast carcinoma?

Answer 23

Question 24

What are the diagnostic procedures for breast carcinoma?

Answer 24

Clincial exam

Radiology (mammography, US, MRI)

Core needle biopsy

Question 25

What this be?

Answer 25

Comedo DCIS

Question 26

What this be?

Answer 26

Epithelial hyperplasia w/o atypia

Question 27

What are the defining characteristics of epithelial hyperplasia?

Answer 27

more than two cell layers are present florid, but architecturally and cytologically benign, hyperplasia (hyperplasia w/o atypia-usual ductal hyperplasia, UDH)

Question 28

What this be?

Answer 28

ALH

Question 29

What are three disorders that fall under proliferative breast dz w/o atypia?

Answer 29

Moderate or florid epithelial hyperplasia w/o atypia Sclerosing adenosis/ complex sclerosing lesion Papilloma

Question 30

What are the four different pathologies of breast carcinoma?

Answer 30

Question 31

What this be?

Answer 31

Sclerosing adenosis (complex sclerosing lesion)

Question 32

Condition?

Answer 32

Paget's Dz of the Nipple (paget cells)

Question 33

Sporadic cases are breast cancer are generally associated with what? Hereditary cases?

Answer 33

Sporadic: Hormonal exposure Hereditary: Germline mutations

Question 34

Left? Right?

Answer 34

Left: Cribiform DCIS Right: Solid DCIS

Question 35

Left? Right?

Answer 35

Left: Paget dz Right: Normal

Question 36

What are the two forms of proliferative breast dz w/ atypia?

Answer 36

Atypical ductal hyperplasia (ADH) Atypical lobular hyperplasia (ALH)

Question 37

What is the racial predisposition to breast carcinoma?

Answer 37

White \> AA \> Asian \> Hispanic

Question 38

What growth pattern of ductal carcinoma in situ?

Answer 38

Comedocarcinoma

Question 39

What this be?

Answer 39

Paget dz

Question 40

What is going on in proliferative breast dz w/o atypia?

Answer 40

Proliferation of ductal epithelium and/or stroma without cellular abnormalities

Question 41

What type of cancer bro?

Answer 41

Ductal carcinoma in situ

Question 42

How does the risk of invasive breast cancer increase with: nonproliferative fibrocystic change, proliferative breast dz w/o atypia, proliferative breast dz w/ atypia?

Answer 42

NP Fibro change: No increased risk Prolif w/o atypia: 1.5-2X risk Prolif w/ atypia: 4-5X risk

Question 43

What left be? What right be?

Answer 43

Left: ADH Right: ALH

Question 44

Name this gene

Answer 44

BRCA2

Question 45

What this be?

Answer 45

Solid DCIS w/ microcalcifications