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Flashcards in 28_Cell Cycle I Deck (9)
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1

What does flow cytometry quantify?

Number cells as a function of DNA content per cell

2

What phase of the cell cycle are the majority of cells in a culture in at a given time?
Which phase contains the least number of cells?

most: G1
least: S

3

What is the result of fusing M-phase and S-phase cells?

chromosomal damage (pulverized DNA) due to compaction of actively dividing DNA.

4

MPFs have 2 subunits; what are they?

CDK & a cyclin

5

What is the effect of increasing cyclin concentration on CDKs?

they are activated => initiate entry into mitosis

6

Which is degraded more, CKDs or cyclins?

cyclins

7

What is the CDK in yeast?

cdc2 kinase -- only has this one

8

When is MPF activity the highest?

M-phase

9

When is the concentration of mitotic cyclins the highest?

end of G2 (peaks just before initiation of M-phase)