Flashcards in 23_Signal Transduction I Deck (16)
Which type of cell signalling requires cells to be in contact? (i.e. both the ligand and the receptor are membrane-bound)
What is the difference between autocrine and paracrine signalling?
autocrine: receptor for signal is on same cell (signalling cell = target cell)
paracrine: receptor for signal is on same cell type
How are endorcrine signals carried through the body?
Which types of receptor based signalling involve a secreted stimulus?
(choose from juxto/auto/para/endocrine)
autocrine, paracrine, endocrine
What is an example of a gas that can act as an extracellular messenger?
What are sterols derived from? How about eiconsanoids?
eicosanoids: arachidonic acid
By definition, second messengers are (proteins/non-protein).
Does the human genome encode more phosphatases or kinases?
>500 kinases; >100 phosphatases
(Kinases/phosphatases) dephosphorylate their substrate.
In reversible phosphorylation, where does the phosphoryl group added to a substrate protein come from?
Kinases transfer phosphoryl groups to which amino acid residues on substrate proteins?
Thr, His, Tyr, Arg, Ser
"So You Think He's Right?"
Which gland is prolactin secreted from?
What does an activated Jak2 phosphorylate?
itself, the receptor, and STAT
What domain on STAT allows it to interact with a phosphorylated Y?
What must happen to STAT before it can dimerize?
it needs to be phosphorylated