23_Signal Transduction I Flashcards Preview

BIOL 331 > 23_Signal Transduction I > Flashcards

Flashcards in 23_Signal Transduction I Deck (16)
1

Which type of cell signalling requires cells to be in contact? (i.e. both the ligand and the receptor are membrane-bound)

juxtacrine

2

What is the difference between autocrine and paracrine signalling?

autocrine: receptor for signal is on same cell (signalling cell = target cell)
paracrine: receptor for signal is on same cell type

3

How are endorcrine signals carried through the body?

via bloodstream

4

Which types of receptor based signalling involve a secreted stimulus?
(choose from juxto/auto/para/endocrine)

autocrine, paracrine, endocrine

5

What is an example of a gas that can act as an extracellular messenger?

NO, CO2

6

What are sterols derived from? How about eiconsanoids?

sterols: cholesterol
eicosanoids: arachidonic acid

7

By definition, second messengers are (proteins/non-protein).

non-protein

8

Does the human genome encode more phosphatases or kinases?

kinases

>500 kinases; >100 phosphatases

9

(Kinases/phosphatases) dephosphorylate their substrate.

phosphatases

10

In reversible phosphorylation, where does the phosphoryl group added to a substrate protein come from?

ATP

11

Kinases transfer phosphoryl groups to which amino acid residues on substrate proteins?

Thr, His, Tyr, Arg, Ser

"So You Think He's Right?"

12

Which gland is prolactin secreted from?

pituitary

13

What does an activated Jak2 phosphorylate?

itself, the receptor, and STAT

14

What domain on STAT allows it to interact with a phosphorylated Y?

SH2

15

What must happen to STAT before it can dimerize?

it needs to be phosphorylated

16

In the Jak-STAT signalling pathway, what serves as a docking site for STAT? (be specific)

phosphorylated tyrosine on the receptor