21_Cell Junctions II Flashcards Preview

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Flashcards in 21_Cell Junctions II Deck (8)
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1

Which cell-cell junctions form the paracellular pathway?

tight junctions

2

Disorders involving thin hair, retinal degradation and limb malformation are a result of mutations in which cell adhesion protein?

cadherin

3

What are symptoms of plakophilin mutations?

kinky hair and fragile skin

4

Where is keratin 14 expressed? What are the consequences of weak keratin 14?

basal cell layer of epidermis

blister in same layer; fragile skin

5

What type of cells make up most of the lens?

Fibre cells

6

How do gap junction connexins maintain lens transparency?

GJs to other cells maintain ion flow and promote crystallin cytoplasmic protein function & structure

7

What is a ocular consequence of gap junction mutations?

cloudy lens

8

What is the cause of Bullous pemphigoid? Symptoms?

autoantibodies against hemidesmosome proteins result in loss of adhesion below the basal cell layer of the dermis.

Sx: blistering