chapter 24-fluoroquinolones

Question 1

pharmacodynamics of fluroquinolones

Answer 1

• interferes with bacterial enzymes needed for bacterial DNA synthesis
• not to be used for kids under 18

Question 2

fluoroquinolones

Answer 2

• broad spectrum abx
• names: “….-floxin” i.e. ciprofloxin, levofloxin, etc
• resistance over prescribing-no longer effective agains gonorrhea or TB

Question 3

pharmacokinetics and ADRs of fluroquinolones

Answer 3

• well absorbed-take on empty stomach (food delays absorption)
• not for children
• spontaneous tendon rupture-could be delayed

Question 4

clinical use of fluroquinolones

Answer 4

• complicated UTI-pyelonephritis, chronic bacterial prostatis
• pneumonia/chronic bronchitis exacerbation
• PCN resistant s. pneumoniae, skin infections/bone and joint infections, infectious diarrhea

Question 5

monitoring on fluroquinolones

Answer 5

• prolonged use of moxifloxacin-ECG shows syncope or torsades de point
• patients with epilepsy, alcohol abuse, or on theophylline-monitored for seizures, CNS irritability

Question 6

Drug to drug reactions with fluroquinolones T.A.D.

Answer 6

drug reactions with:
T: theophylline
A: anticoagulants
D: digoxin
-st. johns wart can have increased photosensitivity