chapter 24 lincosamides

Question 1

pharmacodynamics of lincosamides

Answer 1

• inhibits protein synthesis
• no gram negative activity
• gram positive activity: corynebacterium acnes, gardnarella vaginalis, first line with MRSA

Question 2

ADRs for lincosamides (C.L.I.N.D.A.)

Answer 2

C: colitis
L: liver function
I: IM injection 
N: neuromuscular blockade increase
D: d/c bone marrow deficiency
A: arrhythmia

Question 3

clinical dosing for lincosamides

Answer 3

• 1st line for MRSA in some areas
• infections for PCN allergies
• DRSP infections (s. pneumoniae resistant to PCN, cephalosporins, tetracyclines, sulfonamides)
• dental infections
• 1st line for pts who are pregnant and children
• 2nd line for narrow spectrum aerobic activity

Question 4

Lincosamides

Answer 4

• 2 drugs in this class: lincomycin and clindamycin

- lincomycin is too toxic and rarely used